Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Diacylglycerol Kinase/*metabolism ; Diglycerides/*metabolism ; Phosphatidic Acids/*metabolism ; Signal Transduction/*genetics; Animals ; Diabetes Mellitus/genetics ; Diabetes Mellitus/metabolism ; Diacylglycerol Kinase/antagonists & inhibitors ; Diacylglycerol Kinase/chemistry ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Nervous System Diseases/genetics ; Nervous System Diseases/metabolism ; Protein Isoforms ; Signal Transduction/immunology ; Signal Transduction/physiology

The diacylglycerol kinase family, which can attenuate diacylglycerol signaling and activate phosphatidic acid signaling, regulates various signaling transductions in the mammalian cells. Studies on the regulation of diacylglycerol and phosphatidic acid levels by various enzymes, the identification and characterization of various diacylglycerol and phosphatidic acid-regulated proteins, and the overlap of different diacylglycerol and phosphatidic acid metabolic and signaling processes have revealed the complex and non-redundant roles of diacylglycerol kinases in regulating multiple biochemical and biological networks. In this review article, we summarized recent progress in the complex and non-redundant roles of diacylglycerol kinases, which is expected to aid in restoring dysregulated biochemical and biological networks in various pathological conditions at the bed side.

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NRF-2020R1F1A1071980 National Research Foundation of Korea; NRF-2018R1D1A1B07041381 National Research Foundation of Korea

Keywords: diacylglycerol; diacylglycerol kinase; lipid signaling; phosphatidic acid; tissue microenvironment; tumor microenvironment

0 (Diglycerides)
0 (Phosphatidic Acids)
0 (Protein Isoforms)
EC 2.7.1.107 (Diacylglycerol Kinase)

Date Created: 20200923 Date Completed: 20210315 Latest Revision: 20210315

20221213

PMC7554708

10.3390/ijms21186861

32962151