Uncertainty quantification of bioassay functions for the internal dosimetry of radioiodine.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0376611 Publication Model: Print Cited Medium: Internet ISSN: 1349-9157 (Electronic) Linking ISSN: 04493060 NLM ISO Abbreviation: J Radiat Res Subsets: MEDLINE
    • Publication Information:
      Publication: July 2012- : Oxford : Oxford University Press
      Original Publication: Tokyo : Japan Radiation Research Society
    • Subject Terms:
      Iodine Radioisotopes* ; Radiation Dosage* ; Radiation Monitoring* ; Radiation Protection* ; Radiometry*; Biological Assay/*methods; Humans ; Kinetics ; Monte Carlo Method ; Occupational Exposure/prevention & control ; Probability ; Radiation Exposure/prevention & control ; Thyroid Gland/drug effects ; Thyroid Gland/immunology ; Thyroid Gland/radiation effects ; Uncertainty
    • Abstract:
      Bioassay functions, which are provided by the International Commission on Radiological Protection, are used to estimate the intake activity of radionuclides; however, they include considerable uncertainties in terms of the internal dosimetry for a particular individual. During a practical internal dose assessment, the uncertainty in the bioassay function is generally not introduced because of the difficulty in quantification. Therefore, to clarify the existence of uncertainty in the bioassay function and provide dosimetrists with an insight into this uncertainty, this study attempted to quantify the uncertainty in the thyroid retention function used for radioiodine exposure. The uncertainty was quantified using a probabilistic estimation of the thyroid retention function through the propagation of the distribution of biokinetic parameters by the Monte Carlo simulation technique. The uncertainties in the thyroid retention function, expressed in terms of the scattering factor, were in the ranges of 1.55-1.60 and 1.40-1.50 for within 24 h and after 24 h, respectively. In addition, the thyroid retention function within 24 h was compared with actual measurement data to confirm the uncertainty due to the use of first-order kinetics in the biokinetic model calculation. Significantly higher thyroid uptakes (by a factor of 1.9) were observed in the actual measurements. This study indicates that consideration of the uncertainty in the thyroid retention function can avoid a significant over- and under-estimation of the internal dose, particularly when a high dose is predicted.
      (© The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.)
    • References:
      Ann ICRP. 2007;37(2-4):1-332. (PMID: 18082557)
      Radiat Prot Dosimetry. 2016 Sep;170(1-4):17-20. (PMID: 26541189)
      Ann ICRP. 2015 Sep;44(2):5-188. (PMID: 26494836)
      Ann ICRP. 1993;23(3-4):1-167. (PMID: 7978694)
      Radiat Prot Dosimetry. 2007;123(2):156-70. (PMID: 17062600)
      Rev Med Chil. 2008 Oct;136(10):1288-93. (PMID: 19194625)
      Ann ICRP. 1991;21(1-3):1-201. (PMID: 2053748)
      N Engl J Med. 1980 Nov 6;303(19):1083-8. (PMID: 7421914)
      Health Phys. 1993 Jul;65(1):33-40. (PMID: 8505228)
      Radiat Prot Dosimetry. 2019 Dec 31;187(1):69-76. (PMID: 31135910)
      Ann ICRP. 2017 Dec;46(3-4):1-486. (PMID: 29380630)
      Health Phys. 2003 Apr;84(4):421-35. (PMID: 12705441)
      Health Phys. 2004 Nov;87(5):490-506. (PMID: 15551787)
      Health Phys. 2006 Feb;90(2):114-26. (PMID: 16404169)
      J Clin Invest. 1951 Mar;30(3):301-4. (PMID: 14824280)
      Ann ICRP. 2006;36(1-2):25-327, iii. (PMID: 17188183)
      Radiat Res. 2010 Oct;174(4):496-516. (PMID: 20726703)
      Ann ICRP. 1997;27(3-4):i-x, 1-161. (PMID: 9775348)
      Health Phys. 1967 Oct;13(10):1055-65. (PMID: 6048953)
      Health Phys. 2001 Nov;81(5):492-501. (PMID: 11669202)
      J Nucl Med. 1985 Aug;26(8):884-7. (PMID: 3839845)
      J Nucl Med. 1980 Sep;21(9):835-7. (PMID: 7411215)
      Ann ICRP. 1994;24(1-3):1-482. (PMID: 7726471)
      Indian J Med Res. 2017 Mar;145(3):358-364. (PMID: 28749399)
      Radiat Prot Dosimetry. 2001;95(3):239-47. (PMID: 11605798)
    • Contributed Indexing:
      Keywords: retention function; internal dosimetry; probabilistic estimation; thyroid dose; uncertainty in bioassay
    • Accession Number:
      0 (Iodine Radioisotopes)
    • Publication Date:
      Date Created: 20200915 Date Completed: 20210927 Latest Revision: 20231112
    • Publication Date:
      20240829
    • Accession Number:
      PMC7674691
    • Accession Number:
      10.1093/jrr/rraa081
    • Accession Number:
      32930725