Does 'Dry Hit' vaping of vitamin E acetate contribute to EVALI? Simulating toxic ketene formation during e-cigarette use.

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  • Author(s): Narimani M;Narimani M; da Silva G; da Silva G
  • Source:
    PloS one [PLoS One] 2020 Sep 03; Vol. 15 (9), pp. e0238140. Date of Electronic Publication: 2020 Sep 03 (Print Publication: 2020).
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Ethylenes/*metabolism ; Ketones/*metabolism ; Lung Injury/*pathology ; Vaping/*adverse effects ; Vitamin E/*metabolism; Ethylenes/chemistry ; Ethylenes/toxicity ; Humans ; Ketones/chemistry ; Ketones/toxicity ; Kinetics ; Lung Injury/chemically induced ; Temperature ; Vitamin E/chemistry
    • Abstract:
      Vitamin E acetate (VEA) is strongly linked to the outbreak of electronic-cigarette or vaping product use-associated lung injury (EVALI). It has been proposed that VEA decomposition to ketene-a respiratory poison that damages lungs at low ppm levels-may play a role in EVALI. However, there is no information available on the temperature at which VEA decomposes and how this correlates with the vaping process. We have studied the temperature-dependent kinetics of VEA decomposition using quantum chemical and statistical mechanical modelling techniques, developing a chemical kinetic model of the vaping process. This model predicts that, under typical vaping conditions, the use of VEA contaminated e-cigarette products is unlikely to produce ketene at harmful levels. However, at the high temperatures encountered at low e-cigarette product levels, which produce 'dry hits', ketene concentrations are predicted to reach acutely toxic levels in the lungs (as high as 30 ppm). We therefore hypothesize that dry hit vaping of e-cigarette products containing VEA contributes to EVALI.
      Competing Interests: The authors have declared that no competing interests exist.
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    • Accession Number:
      0 (Ethylenes)
      0 (Ketones)
      1406-18-4 (Vitamin E)
      LEP3SM032A (ketene)
    • Publication Date:
      Date Created: 20200904 Date Completed: 20201028 Latest Revision: 20201028
    • Publication Date:
      20221213
    • Accession Number:
      PMC7470376
    • Accession Number:
      10.1371/journal.pone.0238140
    • Accession Number:
      32881943