Chromatin architecture provides a roadmap to improve our understanding of psychiatric disorders.

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  • Author(s): Hu B;Hu B;Hu B; Won H; Won H; Won H
  • Source:
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2021 Jan; Vol. 46 (1), pp. 234-235.
  • Publication Type:
    News; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
    • Publication Information:
      Publication: 2003- : London : Nature Publishing Group
      Original Publication: [New York, NY] : Elsevier, [c1987-
    • Subject Terms:
      Chromatin* ; Mental Disorders*/genetics; Humans
    • References:
      Watanabe K, Stringer S, Frei O, Umićević Mirkov M, de Leeuw C, Polderman TJC, et al. A global overview of pleiotropy and genetic architecture in complex traits. Nat Genet. 2019;51:1339–48. (PMID: 10.1038/s41588-019-0481-031427789)
      Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, et al. Comprehensive functional genomic resource and integrative model for the human brain. Science. 2018;362:eaat8464. (PMID: 10.1126/science.aat8464305458576413328)
      Mah W, Won H. The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk. Schizophr Res. 2019. https://doi.org/10.1016/j.schres.2019.03.007 . (PMID: 10.1016/j.schres.2019.03.00730894290)
      de Leeuw CA, Mooij JM, Heskes T, Posthuma D. MAGMA: generalized gene-set analysis of GWAS data. PLoS Comput Biol. 2015;11:e1004219. (PMID: 10.1371/journal.pcbi.1004219258857104401657)
      Sey NYA, Hu B, Mah W, Fauni H, McAfee JC, Rajarajan P, et al. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nat Neurosci. 2020. https://doi.org/10.1038/s41593-020-0603-0 . (PMID: 10.1038/s41593-020-0603-0321525377131892)
      Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell. 2019;179:1469–82. (PMID: 10.1016/j.cell.2019.11.020)
    • Grant Information:
      R00 MH113823 United States MH NIMH NIH HHS; R21 DA051921 United States DA NIDA NIH HHS; DP2 MH122403 United States MH NIMH NIH HHS
    • Accession Number:
      0 (Chromatin)
    • Publication Date:
      Date Created: 20200830 Date Completed: 20210623 Latest Revision: 20220102
    • Publication Date:
      20221213
    • Accession Number:
      PMC7688951
    • Accession Number:
      10.1038/s41386-020-00822-5
    • Accession Number:
      32859998