Intraindividual relative deficits in visual memory to lateralize seizure onset in temporal lobe epilepsy.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Diego, CA : Academic Press, c2000-
    • Subject Terms:
      Neuropsychological Tests*; Epilepsy, Temporal Lobe/*psychology ; Functional Laterality/*physiology ; Memory/*physiology ; Memory Disorders/*psychology ; Visual Perception/*physiology; Adult ; Epilepsy, Temporal Lobe/diagnosis ; Female ; Humans ; Male ; Memory Disorders/diagnosis ; Middle Aged ; Retrospective Studies
    • Abstract:
      It is well established that presurgical neuropsychological assessment can assist in lateralizing and localizing focal epileptogenic regions. However, unlike verbal memory impairment, which is a robust and reliable finding in patients with left temporal lobe epilepsy (LTLE), nonverbal memory deficits are less consistently found among patients with right TLE (RTLE). This study aimed to determine whether memory assessment for spatial location in addition to visual content would differentiate patients with RTLE and LTLE. We compared performances between patients with 25 RTLE and 37 patients with LTLE on the Wechsler Advanced Clinical Solutions-Faces (ACS-F) subscales (Faces I, Faces II, Content, and Spatial), verbal-visual memory asymmetry scores, and intelligence quotient (IQ)-visual memory difference scores. Results revealed no significant differences between patients with RTLE and LTLE for any ACS-F memory score. By contrast, groups demonstrated significant differences in memory asymmetry scores (p = .007) and IQ difference scores (p = .006). Thus, visual memory scores in isolation failed to differentiate groups with RTLE and LTLE; however, within-patient differences between visual memory and other cognitive abilities successfully differentiated the groups. These results highlight the importance of using an intraindividual model of neuropsychological assessment to identify relative weaknesses potentially associated with the epileptogenic region.
      Competing Interests: Declaration of competing interest None of the authors have any conflict of interest to disclose.
      (Copyright © 2020 Elsevier Inc. All rights reserved.)
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    • Grant Information:
      R01 NS035140 United States NS NINDS NIH HHS
    • Contributed Indexing:
      Keywords: Face memory; Memory assessment; Neuropsychology; Nondominant hemisphere; Temporal lobe; Visual memory
    • Publication Date:
      Date Created: 20200830 Date Completed: 20210308 Latest Revision: 20211002
    • Publication Date:
      20231215
    • Accession Number:
      PMC7541792
    • Accession Number:
      10.1016/j.yebeh.2020.107370
    • Accession Number:
      32859523