Prospects and Therapeutic Applications of Cardiac Glycosides in Cancer Remediation.

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  • Author(s): Ayogu JI;Ayogu JI;Ayogu JI; Odoh AS; Odoh AS
  • Source:
    ACS combinatorial science [ACS Comb Sci] 2020 Nov 09; Vol. 22 (11), pp. 543-553. Date of Electronic Publication: 2020 Aug 24.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101540531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2156-8944 (Electronic) Linking ISSN: 21568944 NLM ISO Abbreviation: ACS Comb Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Chemical Society
    • Subject Terms:
      Adenosine Triphosphatases/*antagonists & inhibitors ; Antineoplastic Agents/*chemistry ; Cardiac Glycosides/*chemistry ; Enzyme Inhibitors/*chemistry ; Neoplasms/*drug therapy; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cardenolides/metabolism ; Cardiac Glycosides/pharmacology ; Enzyme Inhibitors/pharmacology ; Heart ; Humans ; Metabolome/drug effects ; Potassium/metabolism ; Sodium/metabolism
    • Abstract:
      Active metabolites from natural sources are the predominant molecular targets in numerous biological studies owing to their appropriate compatibility with biological systems and desirable selective toxicities. Thus, their potential for therapeutic development could span a broad scope of disease areas, including pathological and neurological dysfunctions. Cardiac glycosides are a unique class of specialized metabolites that have been extensively applied as therapeutic agents for the treatment of numerous heart conditions, and more recently, they have also been explored as probable antitumor agents. They are a class of naturally derived compounds that bind to and inhibit Na + /K + -ATPase. This study presents cardiac glycosides and their analogues with highlights on their applications, challenges, and prospects as lead compounds for cancer treatment.
    • Contributed Indexing:
      Keywords: Na/K-ATPase; anticancer agent; apoptosis; cardenolides; cardiac glycoside
    • Accession Number:
      0 (Antineoplastic Agents)
      0 (Cardenolides)
      0 (Cardiac Glycosides)
      0 (Enzyme Inhibitors)
      9NEZ333N27 (Sodium)
      EC 3.6.1.- (Adenosine Triphosphatases)
      RWP5GA015D (Potassium)
    • Publication Date:
      Date Created: 20200814 Date Completed: 20210909 Latest Revision: 20210909
    • Publication Date:
      20231215
    • Accession Number:
      10.1021/acscombsci.0c00082
    • Accession Number:
      32786321