Hepatitis C Virus (HCV) Eradication With Interferon-Free Direct-Acting Antiviral-Based Therapy Results in KLRG1+ HCV-Specific Memory Natural Killer Cells.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 2011- : Oxford : Oxford University Press
      Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
    • Subject Terms:
      Antiviral Agents*/therapeutic use ; Hepatitis C, Chronic*/drug therapy; Immunological Memory Cells/*drug effects ; Killer Cells, Natural/*drug effects; Hepacivirus ; Humans ; Immunological Memory Cells/virology ; Interferons ; Killer Cells, Natural/virology ; Lectins, C-Type ; Receptors, Immunologic
    • Abstract:
      Direct acting antiviral therapies rapidly clear chronic hepatitis C virus (HCV) infection and restore natural killer (NK) cell function. We investigated NK-cell memory formation following HCV clearance by examining NK-cell phenotype and responses from control and chronic HCV patients before and after therapy following sustained virologic response at 12 weeks post therapy (SVR12). NK-cell phenotype at SVR12 differed significantly from paired pretreatment samples, with an increase in maturation markers CD16, CD57, and KLRG1. HCV patients possessed stronger cytotoxic responses against HCV-infected cells as compared to healthy controls; a response that further increased following SVR12. The antigen-specific response was mediated by KLRG1+ NK cells, as demonstrated by increased degranulation and proliferation in response to HCV antigen only. Our data suggest that KLRG1+ HCV-specific memory NK cells develop following viral infection, providing insight into their role in HCV clearance and relevance with regard to vaccine design.
      (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].)
    • Contributed Indexing:
      Keywords: hepatitis C virus; innate immunity; memory NK cells; natural killer cells
    • Accession Number:
      0 (Antiviral Agents)
      0 (KLRG1 protein, human)
      0 (Lectins, C-Type)
      0 (Receptors, Immunologic)
      9008-11-1 (Interferons)
    • Publication Date:
      Date Created: 20200811 Date Completed: 20220210 Latest Revision: 20220210
    • Publication Date:
      20240829
    • Accession Number:
      10.1093/infdis/jiaa492
    • Accession Number:
      32777077