[Acquired coagulation disorders].

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  • Author(s): Suzuki N;Suzuki N
  • Source:
    [Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2020; Vol. 61 (7), pp. 779-784.
  • Publication Type:
    Journal Article
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Japan Society Of Clinical Hematology Country of Publication: Japan NLM ID: 2984782R Publication Model: Print Cited Medium: Print ISSN: 0485-1439 (Print) Linking ISSN: 04851439 NLM ISO Abbreviation: Rinsho Ketsueki Subsets: MEDLINE
    • Publication Information:
      Publication: Tokyo : Japan Society Of Clinical Hematology
      Original Publication: Tokyo, Rinsho Ketsueki Kondankai.
    • Subject Terms:
      Blood Coagulation* ; Blood Coagulation Disorders*; Antiphospholipid Syndrome ; Blood Coagulation Tests ; Humans ; Lupus Coagulation Inhibitor ; Partial Thromboplastin Time ; Prothrombin Time
    • Abstract:
      Acquired coagulation inhibitors have become a popular area of research because they cause severe bleeding tendency in many patients. The use of acquired coagulation inhibitors requires rapid and precise diagnosis. Some acquired coagulation inhibitors show prolongation in the activated partial thromboplastin time (APTT) and/or prothrombin time (PT). To diagnose these disorders, mixing test is very useful. However, lupus anticoagulant related disorders, such as lupus anticoagulant hypoprothrombinemia syndrome (LAHPS), are difficult to diagnose because they are sometimes associated with a reduction in factor VIII and are thus difficult to distinguish from acquired hemophilia. Acquired factor XIII deficiency and acquired von Willebrand syndrome (AvWS) are easily overlooked because they show normal value in several patients with APTT and PT. Here I describe the diagnostic method for these disorders. In particular, five acquired coagulation inhibitors that appear to be clinically significant are studied.
    • Contributed Indexing:
      Keywords: APTT mixing test; Acquired coagulation inhibitors; Acquired von Willebrand disease; Lupus anticoagulant
    • Accession Number:
      0 (Lupus Coagulation Inhibitor)
    • Publication Date:
      Date Created: 20200808 Date Completed: 20200924 Latest Revision: 20200924
    • Publication Date:
      20240829
    • Accession Number:
      10.11406/rinketsu.61.779
    • Accession Number:
      32759565