Prognostic Markers of Myelodysplastic Syndromes.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

Publication: 2018- : Basel, Switzerland : MDPI
Original Publication: Kaunas : Lietuvos gydytojų sąjunga

Prognosis*; Biomarkers/*analysis ; Myelodysplastic Syndromes/*diagnosis; Core Binding Factor Alpha 2 Subunit/analysis ; DNA (Cytosine-5-)-Methyltransferases/analysis ; DNA Methyltransferase 3A ; DNA-Binding Proteins/analysis ; Dioxygenases ; Humans ; Mutation/genetics ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/physiopathology ; Phosphoproteins/analysis ; Proto-Oncogene Proteins/analysis ; RNA Splicing Factors/analysis ; Repressor Proteins/analysis ; Serine-Arginine Splicing Factors/analysis

Myelodysplastic syndrome (MDS) is a clonal disease characterized by multilineage dysplasia, peripheral blood cytopenias, and a high risk of transformation to acute myeloid leukemia. In theory, from clonal hematopoiesis of indeterminate potential to hematologic malignancies, there is a complex interplay between genetic and epigenetic factors, including miRNA. In practice, karyotype analysis assigns patients to different prognostic groups, and mutations are often associated with a particular disease phenotype. Among myeloproliferative disorders, secondary MDS is a group of special entities with a typical spectrum of genetic mutations and cytogenetic rearrangements resembling those in de novo MDS. This overview analyzes the present prognostic systems of MDS and the most recent efforts in the search for genetic and epigenetic markers for the diagnosis and prognosis of MDS.

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19-34-60024 Russian Foundation for Basic Research

Keywords: IPSS-R; acute myeloid leukemia; karyotype; microRNA; myelodysplastic syndrome

0 (ASXL1 protein, human)
0 (Biomarkers)
0 (Core Binding Factor Alpha 2 Subunit)
0 (DNA-Binding Proteins)
0 (DNMT3A protein, human)
0 (Phosphoproteins)
0 (Proto-Oncogene Proteins)
0 (RNA Splicing Factors)
0 (RUNX1 protein, human)
0 (Repressor Proteins)
0 (SF3B1 protein, human)
147153-65-9 (SRSF2 protein, human)
170974-22-8 (Serine-Arginine Splicing Factors)
EC 1.13.11.- (Dioxygenases)
EC 1.13.11.- (TET2 protein, human)
EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
EC 2.1.1.37 (DNA Methyltransferase 3A)

Date Created: 20200731 Date Completed: 20210318 Latest Revision: 20211204

20231215

PMC7466347

10.3390/medicina56080376

32727068