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Antibody responses to SARS-CoV-2 in healthy individuals returning to Shenzhen.
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- Author(s): Zhang C;Zhang C; Lin L; Lin L; Tang D; Tang D; Liu F; Liu F; Li M; Li M; Li Q; Li Q; Deng Z; Deng Z; Chu G; Chu G; Gu D; Gu D; Dai Y; Dai Y
- Source:
Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 1154-1157. Date of Electronic Publication: 2020 Aug 02.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
- Publication Information: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss. - Subject Terms: COVID-19 Serological Testing* ; Enzyme-Linked Immunosorbent Assay*; Antibodies, Viral/*blood ; COVID-19/*immunology; Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; Child ; China/epidemiology ; Cross-Sectional Studies ; Female ; Healthy Volunteers ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Middle Aged ; Reagent Kits, Diagnostic ; Reproducibility of Results ; Young Adult
- Abstract: To verify reliability of antibody detection and investigate population immunity to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in the local Chinese population. A cross-sectional study was conducted in Shenzhen to detect anti-coronavirus antibodies including, immunoglobulin G (IgG), immunoglobulin M (IgM), and immunoglobulin A (IgA). In the COVID-19 group, nine patients were enrolled after diagnosis. In the control group, 1589 individuals without clinical symptoms (cough, fever, and fatigue) and returning from outside Shenzhen were enrolled. The first study enrollment occurred at the end of February 2020; the final study visit was 18 March 2020. In the COVID-19 group, the seven of nine patients were positive for IgM, IgG, and IgA. Meanwhile, six of the 1589 healthy individuals were found to be weakly positive for IgG. According to SARS-CoV-2 nucleic acid tests, the six individuals were all negative. Strong supplemental support for clinical information can be provided by antibody detection, especially for IgA. According to comparison with overseas reports, the infection rate of the Chinese population outside Shenzhen, China, is significantly low, so most of the population in China is still susceptible. Hence, social distancing measures are still inevitable until a vaccine is developed successfully.
(© 2020 Wiley Periodicals LLC.) - References: WHO. Coronavirus disease (COVID-2019) situation reports. July 21, 2020. https://www.who.int/docs/default-source/wha-70-and-phe/20200721-covid-19-sitrep-183.pdf?sfvrsn=b3869b3_2.
National Health Commission of the People's Republic of China. 21 July, 2020. http://www.nhc.gov.cn/xcs/yqfkdt/202007/13f951072dfa4c3a8ebf396e308847d7.shtml.
Sakamoto S, Puttalam W, Vimolmangkang S, Phoolcharoen W, Shoyama Y, Tanaka H. Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites. J Nat Med. 2018;72(1):32-42.
Zhou P, Yang X-L, Wang X-G, et al: Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. 2020:2020.2001.2022.914952.
Ge XY, Li JL, Yang XL, et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature. 2013;503(7477):535-538.
Jin Li, Guangming Ye, Liangjun Chen, Jiajun Wang, Yirong Li. Causes and countermeasures of false-negative results for 2019 novel coronavirus nucleic acid test. Chin J Lab Med. 2020;43(03):221-225.
Zhao J, Yuan Q, Wang H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis. 2020.
Choe J-Y, Kim JW, Kwon HH, et al. Diagnostic performance of immunochromatography assay for rapid detection of IgM and IgG in coronavirus disease 2019. J Med Virol. 2020. https://doi.org/10.1002/jmv.26060.
Xiang F, Wang X, He X, et al. Antibody detection and dynamic characteristics in patients with COVID-19. Clin Infect Dis. 2020.
Xiang J, Yan M, Li H, et al. Evaluation of enzyme-linked immunoassay and colloidal gold-immunochromatographic assay kit for detection of novel coronavirus (SARS-CoV-2) causing an outbreak of pneumonia (COVID-19). 2020.
Long Q-X, Liu B-Z, Deng H-J, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med. 2020;26:845-848.
Hendrik S, Gunther H, Martin E, Matthias S. Vorläufiges Ergebnis und Schlussfolgerungen der COVID-19 Case-Cluster-Study (Gemeinde Gangelt). 2020:4-9.
The Boston Globe. A test of 200 people just outside Boston found that 32% had been exposed to the coronavirus, compared to an official rate of 2%. https://www.bostonglobe.com/2020/04/17/business/nearly-third-200-blood-samples-taken-chelsea-show-exposure-coronavirus/.
Fine PEM. Herd immunity: history, theory, practice. Epidemiol Rev. 1993;15(2):265-302.
Xu X, Sun J, Nie S, et al.: Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China. 2020:1-3. - Contributed Indexing: Keywords: COVID-19; IgA; IgG; IgM; SARS-CoV-2
- Accession Number: 0 (Antibodies, Viral)
0 (Immunoglobulin A)
0 (Immunoglobulin G)
0 (Immunoglobulin M)
0 (Reagent Kits, Diagnostic) - Publication Date: Date Created: 20200726 Date Completed: 20210114 Latest Revision: 20210114
- Publication Date: 20231215
- Accession Number: 10.1002/jmv.26355
- Accession Number: 32710647
- Source:
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