The Regulation of E3 Ubiquitin Ligases Cbl and its Cross-talking in Bone Homeostasis.

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  • Author(s): Yang X;Yang X; Hao D; Hao D; He B; He B
  • Source:
    Current stem cell research & therapy [Curr Stem Cell Res Ther] 2021; Vol. 16 (6), pp. 683-687.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101272517 Publication Model: Print Cited Medium: Internet ISSN: 2212-3946 (Electronic) Linking ISSN: 1574888X NLM ISO Abbreviation: Curr Stem Cell Res Ther Subsets: MEDLINE
    • Publication Information:
      Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2006-
    • Subject Terms:
      Homeostasis* ; Ubiquitin-Protein Ligases*/genetics; Bone and Bones/*physiology ; Proto-Oncogene Proteins c-cbl/*genetics; Cell Differentiation ; Humans ; Osteoclasts ; Phosphatidylinositol 3-Kinases
    • Abstract:
      The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular proliferation and migration. Whereas, the excessive differentiation of osteoclast and/or its overexpressing of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation. Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted for in-depth exploring Cbl's definite role during osteoclastogenesis, as well as its cross talking with other signaling pathways (such as: Src and PI3K signaling) in bone homeostasis. Herein, our current study aims to briefly conclude the current studies of osteoclastogenesis and the regulatory role of Cbl, as well as its cross-talking in bone homeostasis.
      (Copyright© Bentham Science Publishers; For any queries, please email at [email protected].)
    • Grant Information:
      2018HJCG-08 Shaanxi provincial Science and technology department, science and technology achievement transfer and promotion plan-award achievement transformation project, P.R. China; 2017115 SF/YX009 Xi'an Science and Technology Bureau, Social Development Public Project
    • Contributed Indexing:
      Keywords: Cbl; E3 ubiquitin ligases; PI3K; Src; bone homeostasis; osteoclast.
    • Accession Number:
      EC 2.3.2.27 (Proto-Oncogene Proteins c-cbl)
      EC 2.3.2.27 (Ubiquitin-Protein Ligases)
      EC 6.3.2.- (CBL protein, human)
    • Publication Date:
      Date Created: 20200713 Date Completed: 20211029 Latest Revision: 20211029
    • Publication Date:
      20221213
    • Accession Number:
      10.2174/1574888X15666200712191623
    • Accession Number:
      32652923