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Low-carbohydrate diets and type 2 diabetes treatment: a meta-analysis of randomized controlled trials.
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- Author(s): Silverii GA;Silverii GA; Botarelli L; Botarelli L; Dicembrini I; Dicembrini I; Girolamo V; Girolamo V; Santagiuliana F; Santagiuliana F; Monami M; Monami M; Mannucci E; Mannucci E
- Source:
Acta diabetologica [Acta Diabetol] 2020 Nov; Vol. 57 (11), pp. 1375-1382. Date of Electronic Publication: 2020 Jul 08.- Publication Type:
Journal Article; Meta-Analysis- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms: Diet, Carbohydrate-Restricted*; Diabetes Mellitus, Type 2/*diet therapy; Adult ; Aged ; Blood Glucose/metabolism ; Body Weight ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Randomized Controlled Trials as Topic ; Risk Factors ; Weight Loss
- Abstract: Aim: To assess whether LC diets are associated with long-term improvement in glycemic control and weight loss in people with T2DM, and their cardiovascular and renal safety.
Methods: Meta-analysis of randomized controlled trials lasting more than 3 months, retrieved through extensive search on PubMed, Embase, ClinicalTrial.gov, Cochrane databases up to March 1st, comparing LC diets and balanced carbohydrate diets in people with T2DM.
Results: We retrieved 37 trials, including 3301 patients. Average carbohydrate intake in LC diets was 36% of total energy. LC diets were associated with significant reduction of HbA1c at 3 months (MD - 0.17%, 95% CI - 0.27, - 0.07), no difference at 6 and 12 months, and significant increase at 24 months (MD 0.23%, 95% CI MD 0.02, 0.44). VLC diets were associated with significant HbA1c reduction at 3 and 6 months (MD - 0.43% - 0.60, - 0.26%, and MD - 0.40% 95% CI - 0.59, - 0.22, respectively), but not at 12 and 24 months. LC diets were associated with significant BMI reduction at 6 months (- 1.35 kg/m 2 95% CI, - 2.18, - 0.52), but not at other time points. Only a minority of trials reported data on renal function, so renal safety could not be assessed. No significant differences in body weight, lipid profile, or blood pressure were found in the long term.
Conclusion: LC diets may produce small short-term improvements in HbA1c and weight, which are not maintained in the long term. Data on their renal safety are insufficient. - References: Care D, Suppl SS (2019) 5. Lifestyle management: standards of medical care in diabetesd2019. Diabetes Care 42(January):S46–S60.
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- Accession Number: 0 (Blood Glucose)
- Publication Date: Date Created: 20200709 Date Completed: 20201207 Latest Revision: 20210122
- Publication Date: 20231215
- Accession Number: 10.1007/s00592-020-01568-8
- Accession Number: 32638087
- Source:
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