Association between rotavirus gastroenteritis and intussusception: suggested evidence from a retrospective study in claims databases in the United States.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101572652 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-554X (Electronic) Linking ISSN: 21645515 NLM ISO Abbreviation: Hum Vaccin Immunother Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Philadelphia, PA : Taylor & Francis
      Original Publication: Austin, Tex. : Landes Bioscience
    • Subject Terms:
      Gastroenteritis*/epidemiology ; Intussusception*/epidemiology ; Intussusception*/etiology ; Rotavirus* ; Rotavirus Infections*/complications ; Rotavirus Infections*/epidemiology ; Rotavirus Vaccines*; Humans ; Infant ; Retrospective Studies ; United States/epidemiology
    • Abstract:
      The etiology of intussusception (IS), a serious gastrointestinal obstruction, remains unclear. Limited evidence suggests a role for viral infection. We investigated the risk of IS after rotavirus gastroenteritis (RV GE) in the first year of life. In this retrospective, self-controlled case series (SCCS), we assessed the risk of IS after RV GE using data from United States administrative claims databases. Incidence rate ratios (IRR) of IS were calculated for the 7- and 21-day risk periods after RV GE (main analysis) or after fracture (sensitivity analysis). A total of 290,912,068 subjects were screened; 42 presented claims for RV GE and IS, and 66 for fracture and IS. The IRRs of IS after RV GE were 79.6 (95% confidence interval, CI: 38.6-164.4) and 25.5 (95% CI: 13.2-49.2) in the 7- and 21-day risk periods. The sensitivity analysis showed an association between IS and fracture for both periods, suggesting potential confounding. Post-hoc analyses did not confirm the association between fracture and IS but suggested a potential association between RV GE and IS. A temporal association between RV GE and IS was detected using claims databases. Due to some limitations of the data sources, this association should be further investigated.
    • References:
      Stat Med. 2018 Feb 20;37(4):643-658. (PMID: 29094391)
      Pediatrics. 2005 Jan;115(1):78-82. (PMID: 15629984)
      J Pediatr. 2010 May;156(5):761-5. (PMID: 20138300)
      J Clin Virol. 2014 Dec;61(4):579-84. (PMID: 25464971)
      Epidemiol Infect. 2011 Dec;139(12):1805-17. (PMID: 21849099)
      Vaccine. 2004 Jan 26;22(5-6):569-74. (PMID: 14741146)
      Eur Respir J. 2018 Mar 29;51(3):. (PMID: 29563170)
      Pediatrics. 2008 May;121(5):e1125-32. (PMID: 18450856)
      J Infect Dev Ctries. 2013 Jan 15;7(1):28-35. (PMID: 23324817)
      Pediatr Emerg Care. 2012 Sep;28(9):842-4. (PMID: 22929138)
      Vaccine. 2004 May 7;22(15-16):2064-70. (PMID: 15121324)
      Vaccine. 2012 Jun 29;30(31):4585-7. (PMID: 22580356)
      Stat Med. 2006 May 30;25(10):1768-97. (PMID: 16220518)
      BMJ. 2016 Sep 12;354:i4515. (PMID: 27618829)
      PLoS One. 2013 Jul 22;8(7):e68482. (PMID: 23894308)
      Pediatr Infect Dis J. 2015 Jul;34(7):763-8. (PMID: 26069948)
      Int J Epidemiol. 2019 Aug 1;48(4):1316-1326. (PMID: 30879038)
      Clin Colon Rectal Surg. 2017 Feb;30(1):30-39. (PMID: 28144210)
      J Med Virol. 1978;2(3):265-69. (PMID: 212529)
      Hum Vaccin Immunother. 2017 Feb;13(2):445-449. (PMID: 28075671)
      Pediatrics. 2016 Sep;138(3):. (PMID: 27558938)
      Hum Vaccin Immunother. 2018 Jul 3;14(7):1782-1790. (PMID: 29533129)
      Am J Dis Child. 1992 Nov;146(11):1331-3. (PMID: 1415074)
      Vaccine. 2019 Jul 26;37(32):4587-4593. (PMID: 30851968)
      J Infect Dis. 2012 Dec 1;206(11):1652-9. (PMID: 23048170)
      Pediatr Surg Int. 2019 Mar;35(3):373-381. (PMID: 30478702)
      Expert Rev Vaccines. 2018 Dec;17(12):1135-1141. (PMID: 30407079)
      J Clin Microbiol. 2006 Sep;44(9):3371-3. (PMID: 16954276)
      J Infect Dis. 2004 Apr 15;189(8):1382-7. (PMID: 15073674)
      Clin Infect Dis. 2017 Sep 1;65(5):840-850. (PMID: 28444323)
      J Pediatr. 2006 Oct;149(4):452-60. (PMID: 17011313)
      Clin Infect Dis. 2014 Jan;58(1):61-8. (PMID: 24092802)
    • Contributed Indexing:
      Keywords: Rotavirus gastroenteritis; claims databases; intussusception; self-controlled case series
    • Accession Number:
      0 (Rotavirus Vaccines)
    • Publication Date:
      Date Created: 20200702 Date Completed: 20210621 Latest Revision: 20210621
    • Publication Date:
      20240829
    • Accession Number:
      PMC7872044
    • Accession Number:
      10.1080/21645515.2020.1770514
    • Accession Number:
      32609045