Duloxetine Induced Hyponatremia.

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  • Author(s): Şahan E; Parlakkaya Yıldız FB
  • Source:
    Turk psikiyatri dergisi = Turkish journal of psychiatry [Turk Psikiyatri Derg] 2019 Winter; Vol. 30 (4), pp. 287-289.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English; Turkish
  • Additional Information
    • Transliterated Title:
      Duloksetine Bağlı Hiponatremi.
    • Source:
      Publisher: Türkiye Sinir ve Ruh Sağliği Derneği Country of Publication: Turkey NLM ID: 9425936 Publication Model: Print Cited Medium: Internet ISSN: 2651-3463 (Electronic) Linking ISSN: 13002163 NLM ISO Abbreviation: Turk Psikiyatri Derg Subsets: MEDLINE
    • Publication Information:
      Original Publication: Ankara : Türkiye Sinir ve Ruh Sağliği Derneği
    • Subject Terms:
      Antidepressive Agents/*adverse effects ; Anxiety Disorders/*drug therapy ; Duloxetine Hydrochloride/*adverse effects ; Hyponatremia/*diagnosis ; Serotonin and Noradrenaline Reuptake Inhibitors/*adverse effects; Diagnosis, Differential ; Female ; Humans ; Hyponatremia/chemically induced ; Middle Aged
    • Abstract:
      Hyponatremia can be asymptomatic or have a wide range of clinical presentations such as headaches, muscle cramps, nausea, seizures, coma, cerebral edema and may even result in death. Despite it has been suggested that duloxetine has a relatively less risk of hyponatraemia, the number of case reports are increasing. A 45- year old female patient with complaints of fear, anxiety, sleeplessness and headache was started on duloxetine (30 mg/day). In the first week of the treatment, she was admitted to the emergency service with dizziness, dry mouth, polyuria and polydipsia. She had to be transferred to the intensive care unit because of agitation, loss of consciousness and a generalized tonic-clonic seizure. Blood levels of Sodium (Na+), Potassium (K+) and Chlorine (Cl-) were, respectfully, 121 mmol/L, 2.7 mmol/L and 87 mmol/L. Brain imaging displayed cerebral edema. Electrolyte levels were regulated with saline infusions. Amitriptyline was initiated for the ongoing headache and anxiety. In outpatient visits, hyponatremia did not recur in the following 3 months. Low dose duloxetine was associated with severe hyponatremia signs and symptoms in an individual who was not previously considered as high risk for hyponatraemia. The patient's history did not reveal any complaints related to hyponatremia when she was treated with sertraline two years ago. Based on these, we discussed the risk factors for hyponatremia and risky antidepressant classes.
    • Accession Number:
      0 (Antidepressive Agents)
      0 (Serotonin and Noradrenaline Reuptake Inhibitors)
      9044SC542W (Duloxetine Hydrochloride)
    • Publication Date:
      Date Created: 20200629 Date Completed: 20200921 Latest Revision: 20200921
    • Publication Date:
      20231215
    • Accession Number:
      32594491