Carbapenems versus ciprofloxacin/metronidazole for decreasing complications and hospital stay following complicated acute appendicitis surgery: A prospective cohort in an Ecuadorian population.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Transliterated Title:
      Carbapenémicos vs. ciprofloxacino/metronidazol en la disminución de las complicaciones y de la estancia hospitalaria tras cirugía por apendicitis aguda complicada: cohorte prospectiva en una población ecuatoriana.
    • Source:
      Publisher: Permanyer Country of Publication: Mexico NLM ID: 0372736 Publication Model: Print Cited Medium: Internet ISSN: 2444-054X (Electronic) Linking ISSN: 00097411 NLM ISO Abbreviation: Cir Cir Subsets: MEDLINE
    • Publication Information:
      Publication: 2018- : [Mexico City] : Permanyer
      Original Publication: México, D.F. : Academia Mexicana de Cirugía
    • Subject Terms:
      Appendectomy*; Anti-Bacterial Agents/*therapeutic use ; Appendicitis/*drug therapy ; Carbapenems/*therapeutic use ; Ciprofloxacin/*therapeutic use ; Metronidazole/*therapeutic use; Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Antibiotic Prophylaxis ; Appendicitis/complications ; Appendicitis/epidemiology ; Appendicitis/surgery ; Ciprofloxacin/administration & dosage ; Comorbidity ; Drug Therapy, Combination ; Ecuador/epidemiology ; Emergencies ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Metronidazole/administration & dosage ; Middle Aged ; Postoperative Complications/prevention & control ; Prospective Studies ; Sepsis/drug therapy ; Sepsis/etiology ; Young Adult
    • Abstract:
      Background: After appendectomy due to complicated acute appendicitis (CAA), there are some alternatives as antibiotic scheme: ciprofloxacin/metronidazole; as well as monoscheme based on carbapenems: ertapenem, meropenem, and imipenem.
      Aim: This study aims to prove the efficacy of carbapenems versus ciprofloxacin/metronidazole in CAA post-operative management in terms of preventing complications during post-operative period and decreasing hospital stay.
      Materials and Methods: This was an observational, analytical, longitudinal, and prospective cohort study (March 2014-November 2016). Patients were classified into two groups, according to the prescribed antibiotic scheme: some carbapenems or ciprofloxacin/metronidazole.
      Results: Ninety-eight patients were enrolled. There was an requirement for antibiotic therapy rotation only in the ciprofloxacin/metronidazole (7/49, 14.3%; p = 0.004). Carbapenems reached a mean hospital stay of 4.45 days, in contrast with ciprofloxacin/metronidazole, 8.29 days (p = 0.020). In post-surgical follow-up, there were more cases of curative resolution in the group in the carbapenems group (35/49 vs. 15/49 p < 0.001) as well as a greater number of cases with some late infection in the ciprofloxacin/metronidazole group (1/49 vs. 10/49, p = 0.010).
      Conclusion: In the post-operative management of CAA, carbapenems represent an important indication to be considered as first-line antibiotic therapy.
      (Copyright: © 2020 Permanyer.)
    • Contributed Indexing:
      Keywords: Apendicitis; Appendicitis; Carbapenems; Carbapenémicos; Ciprofloxacin; Ciprofloxacino; Metronidazol; Metronidazole; Periodo posoperatorio; Post-operative period
      Local Abstract: [Publisher, Spanish; Castilian] Tras la cirugía por apendicitis aguda complicada existen varias alternativas de esquema antibiótico, entre las que destacan ciprofloxacino/metronidazol, o bien monoterapia con algún carbapenémico, como ertapenem, meropenem e imipenem. [Publisher, Spanish; Castilian] Determinar la eficacia de los carbapenémicos en comparación con ciprofloxacino/metronidazol en el manejo posquirúrgico de la apendicitis aguda complicada, en términos de prevención de complicaciones durante el ­posoperatorio y de reducción de la estancia hospitalaria. [Publisher, Spanish; Castilian] Estudio observacional, analítico, longitudinal, prospectivo y de cohorte, de marzo de 2014 a noviembre de 2016. Los pacientes fueron clasificados en dos grupos según el esquema antibiótico prescrito: un carbapenémico o ciprofloxacino/metronidazol. [Publisher, Spanish; Castilian] Se seleccionaron 98 pacientes. Solo hubo necesidad de rotación de antibiótico en el grupo de ciprofloxacino/metronidazol (7 de 49, 14.3%; p = 0.004). En el grupo de carbapenémico, la media de estancia hospitalaria fue de 4.45 días, y en el grupo de ciprofloxacino/metronidazol fue de 8.29 días (p = 0.020). En el seguimiento posquirúrgico hubo más casos de resolución curativa en el grupo de carbapenémico (35 de 49 vs. 15 de 49; p < 0.001), así como un mayor número de casos con alguna infección tardía en el grupo de ciprofloxacino/metronidazol (1 de 49 vs. 10 de 49; p < 0.001). [Publisher, Spanish; Castilian] En el manejo posquirúrgico de la apendicitis aguda complicada, los carbapenémicos representan una importante indicación que debe considerarse como antibioticoterapia de primera línea.
    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Carbapenems)
      140QMO216E (Metronidazole)
      5E8K9I0O4U (Ciprofloxacin)
    • Publication Date:
      Date Created: 20200616 Date Completed: 20210517 Latest Revision: 20220415
    • Publication Date:
      20221213
    • Accession Number:
      10.24875/CIRU.19001275
    • Accession Number:
      32538990