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Sodium-glucose cotransporter 2 inhibitors compared with other glucose-lowering drugs in Japan: Subanalyses of the CVD-REAL 2 Study.
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- Author(s): Kohsaka S;Kohsaka S; Takeda M; Takeda M; Bodegård J; Bodegård J; Thuresson M; Thuresson M; Kosiborod M; Kosiborod M; Yajima T; Yajima T; Wittbrodt E; Wittbrodt E; Fenici P; Fenici P
- Source:
Journal of diabetes investigation [J Diabetes Investig] 2021 Jan; Vol. 12 (1), pp. 67-73. Date of Electronic Publication: 2020 Jul 26.- Publication Type:
Comparative Study; Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Asian Association for the Study of Diabetes and Blackwell Pub. Asia Country of Publication: Japan NLM ID: 101520702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1124 (Electronic) Linking ISSN: 20401116 NLM ISO Abbreviation: J Diabetes Investig Subsets: MEDLINE
- Publication Information: Original Publication: Tokyo : Asian Association for the Study of Diabetes and Blackwell Pub. Asia
- Subject Terms: Biomarkers/*analysis ; Cardiovascular Diseases/*prevention & control ; Diabetes Mellitus, Type 2/*drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/*administration & dosage ; Hypoglycemic Agents/*administration & dosage ; Sodium-Glucose Transporter 2 Inhibitors/*administration & dosage; Blood Glucose/analysis ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/pathology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/pathology ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Female ; Follow-Up Studies ; Glycated Hemoglobin/analysis ; Humans ; Hypoglycemic Agents/adverse effects ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
- Abstract: There are limited data on cardiovascular efficacy and safety of type 2 diabetes therapies in Japan, where treatments are characterized by lower metformin use and higher dipeptidyl peptidase-4 inhibitor (DPP4i) use versus other countries. We investigated the cardiovascular outcomes in Japanese patients with type 2 diabetes initiating sodium-glucose cotransporter 2 inhibitors (SGLT2i) matched 1:1 to patients initiating other glucose-lowering drugs (33,890 patients/group) or DPP4i (9,876 patients/group). SGLT2i initiation was associated with lower risks (hazard ratio of in-hospital death [death] 0.56, 95% confidence interval [CI] 0.47-0.67; hospitalization for heart failure 0.75, 95% CI 0.64-0.89; composite of hospitalization for heart failure or death 0.65, 95% CI 0.58-0.74 and stroke 0.66, 95% CI 0.52-0.84 versus other glucose-lowering drugs and lower risks of death 0.52, 95% CI 0.36-0.73) and composite of hospitalization for heart failure or death (0.65, 95% CI 0.51-0.83) versus DPP4i. In conclusion, SGLT2i initiators had lower risks of cardiovascular events versus other glucose-lowering drug initiators and, uniquely, versus DPP4i initiators in Japanese real-world practice.
(© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.) - References: J Diabetes Investig. 2021 Jan;12(1):67-73. (PMID: 32530554)
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Diabetologia. 2018 Oct;61(10):2098-2107. (PMID: 30132034) - Grant Information: AstraZeneca
- Contributed Indexing: Keywords: Cardiovascular event; Sodium-glucose cotransporter 2; Type 2 diabetes
- Accession Number: 0 (Biomarkers)
0 (Blood Glucose)
0 (Dipeptidyl-Peptidase IV Inhibitors)
0 (Glycated Hemoglobin A)
0 (Hypoglycemic Agents)
0 (Sodium-Glucose Transporter 2 Inhibitors)
0 (hemoglobin A1c protein, human) - Publication Date: Date Created: 20200613 Date Completed: 20211004 Latest Revision: 20240330
- Publication Date: 20240330
- Accession Number: PMC7779275
- Accession Number: 10.1111/jdi.13321
- Accession Number: 32530554
- Source:
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