Multimorbidity in a cohort of middle-aged women: Risk factors and disease clustering.

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  • Additional Information
    • Source:
      Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Ireland NLM ID: 7807333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4111 (Electronic) Linking ISSN: 03785122 NLM ISO Abbreviation: Maturitas Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier/North Holland Biomedical Press
      Original Publication: Amsterdam, Elsevier/North Holland Biomedical Press.
    • Subject Terms:
      Multimorbidity*; Depression/*epidemiology ; Diabetes Mellitus/*epidemiology ; Hypertension/*epidemiology ; Obesity/*epidemiology ; Osteoarthritis/*epidemiology; Adult ; Aged ; Aged, 80 and over ; Chile/epidemiology ; Cholesterol, HDL/blood ; Cluster Analysis ; Employment/statistics & numerical data ; Female ; Humans ; Middle Aged ; Postmenopause ; Prospective Studies ; Risk Factors ; Triglycerides/blood
    • Abstract:
      Objective: We aimed to evaluate which risk factors in middle-aged women are associated with higher risk of multimorbidity in older age.
      Study Design: We conducted a prospective cohort study from 1990 to 1993 in Santiago de Chile, Chile among women aged 40-59 (at baseline). Diagnosed illnesses were retrieved from national health records in 2020.
      Main Outcome Measures: Clinical and laboratory evaluation was conducted.
      Results: 1066 women were followed-up for a mean of 27.8 years, after which 49.7% presented multimorbidity. These women, as compared with those without multimorbidity, were more likely at baseline to have had obesity (20.4% vs. 8.6%, p < 0.001); be post-menopause (47.2% vs. 40.5%; p < 0.03); have jobs that did not require a qualification (74.2% vs. 56.0%, p < 0.001); arterial hypertension (19.8% vs 14.4%, p < 0.018); lower HDL-cholesterol (51.3 ± 12.9 vs. 53.6±12.7 mg/dL, p < 0.005); and higher triglyceride levels (136.0 ± 65.0 vs. 127.0 ± 74.0 mg/dL, p = 0.028). Hypertension was associated in 22.0% of women with diabetes, in 20.9% with osteoarthritis and 14.0% with depression. Osteoarthritis was also associated with diabetes mellitus (8.3%) and depression (7.8%). Diabetes mellitus, in addition to hypertension and osteoarthritis, was associated with depression (6.4%). In a logistic regression model, we observed that obesity in middle-aged women was the strongest risk factor for multimorbidity in the elderly (OR: 2.48; 95% CI, 1.71-3.61), followed by having a job that did not require a qualification (OR: 2.18; 95% CI, 1.67-2.83) and having a low HDL-cholesterol level (OR: 1.31; 95% CI, 1.02-1.68).
      Conclusions: Multimorbidity was highly prevalent in this older female population. Obesity in middle-aged women was the strongest risk factor for multimorbidity at older age. These results are relevant for Chile and other countries with similar population profiles.
      (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
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    • Contributed Indexing:
      Keywords: Ageing; Aging; Elder; Multimorbidity; Obesity; Risk factors; Women
    • Accession Number:
      0 (Cholesterol, HDL)
      0 (Triglycerides)
    • Publication Date:
      Date Created: 20200606 Date Completed: 20200924 Latest Revision: 20200924
    • Publication Date:
      20231215
    • Accession Number:
      PMC7284304
    • Accession Number:
      10.1016/j.maturitas.2020.04.016
    • Accession Number:
      32498936