Role of cytokines in the clinical manifestation of exophthalmia in newborn calves with tropical theileriosis.

Publisher: Wiley Country of Publication: England NLM ID: 7910948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3024 (Electronic) Linking ISSN: 01419838 NLM ISO Abbreviation: Parasite Immunol Subsets: MEDLINE

Original Publication: Oxford, Wiley

Theileria annulata*/immunology; Cattle Diseases/*parasitology ; Cytokines/*immunology ; Exophthalmos/*veterinary ; Theileriasis/*immunology; Animals ; Animals, Newborn ; Cattle ; Cattle Diseases/immunology ; Exophthalmos/immunology ; Host-Parasite Interactions ; Tumor Necrosis Factor-alpha/blood

The present study aimed to evaluate the pathology of the exophthalmia and the host-immune response in naturally Theileria annulata-infected calves. The newborn calves detected positive for theileriosis were grouped into calves with theileriosis and absence of exophthalmia (n = 30), and calves with theileriosis and the presence of exophthalmia (n = 13). Sixteen healthy calves, free from any haemoprotozoal infection, were kept as healthy controls. A significantly (P ≤ .001) higher circulating levels of tumour necrosis factor-α (TNF-α) and interleukin-10 (IL-10) were estimated in diseased calves with and without exophthalmia as compared to healthy controls. Contrarily, significantly (P ≤ .01) lower interferon-γ (IFN-γ) level was estimated in diseased calves. The diseased calves with exophthalmia revealed significantly higher levels of TNF-α (P ≤ .001) and IL-10 (P ≤ .006) as compared to the diseased calves without exophthalmia. The diseased calves were not found to have an elevated intraocular pressure; rather they had significantly (P ≤ .001) lower intraocular pressure compared to the healthy controls. An elevated systemic TNF-α level might be attributed to the exophthalmia in calves with tropical theileriosis. The elevated circulatory IL-10 and reduced IFN-γ levels could be one of the strategies of Theileria annulata to escape the host immunity.
(© 2020 John Wiley & Sons Ltd.)

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Keywords: Theileria annulata; interferon-γ; interleukin-10; transforming growth factor-β; tumour necrosis factor-α

0 (Cytokines)
0 (Tumor Necrosis Factor-alpha)

Date Created: 20200605 Date Completed: 20210211 Latest Revision: 20210211

20231215

10.1111/pim.12761

32497247