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Characterization of patients with diabetes who were incidentally found to be glutamic acid decarboxylase autoantibody-positive by bridging-type enzyme-linked immunosorbent assay.
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- Author(s): Kawasaki E;Kawasaki E; Fukuyama T; Fukuyama T; Uchida A; Uchida A; Sagara Y; Sagara Y; Tamai H; Tamai H; Nakano Y; Nakano Y; Tojikubo M; Tojikubo M; Hiromatsu Y; Hiromatsu Y; Koga N; Koga N
- Source:
Journal of diabetes investigation [J Diabetes Investig] 2020 Nov; Vol. 11 (6), pp. 1507-1510. Date of Electronic Publication: 2020 Jun 28.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Asian Association for the Study of Diabetes and Blackwell Pub. Asia Country of Publication: Japan NLM ID: 101520702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1124 (Electronic) Linking ISSN: 20401116 NLM ISO Abbreviation: J Diabetes Investig Subsets: MEDLINE
- Publication Information: Original Publication: Tokyo : Asian Association for the Study of Diabetes and Blackwell Pub. Asia
- Subject Terms: Autoantibodies/*blood ; Biomarkers/*blood ; Diabetes Mellitus, Type 2/*immunology ; Glutamate Decarboxylase/*immunology; Adult ; Autoantibodies/immunology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Incidental Findings ; Japan/epidemiology ; Male ; Mass Screening ; Middle Aged ; Prognosis
- Abstract: This study aimed to characterize diabetic patients incidentally found to be positive for glutamic acid decarboxylase autoantibodies (GADA) in general practice. Using bridging-type enzyme-linked immunosorbent assay, we screened 1,040 patients with phenotypic type 2 diabetes for GADA, finding 25 (2.4%) to be positive. However, on retesting, with a median interval of 19 days, 44% of GADA-positive patients turned negative (Disappearing Group). The mean age at diabetes onset was significantly higher (P < 0.05) and GADA titers at first determination were significantly lower (P < 0.001) in the Disappearing Group compared with the Persistent Positive Group. On initial screening, all patients in the Disappearing Group had GADA titers of <6.5 U/mL. The current study showed that a portion of phenotypic type 2 diabetic patients incidentally identified as GADA-positive were falsely positive, and that to avoid the misclassification, remeasurement of GADA is essential in cases showing very low titers.
(© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.) - References: Diabetes. 2010 Feb;59(2):416-22. (PMID: 19864397)
Diabetologia. 2005 Nov;48(11):2195-9. (PMID: 16193287)
Clin Chim Acta. 2008 Feb;388(1-2):130-4. (PMID: 18023278)
J Diabetes Investig. 2017 Jul;8(4):475-479. (PMID: 27863109)
Clin Chim Acta. 2003 May;331(1-2):55-9. (PMID: 12691864)
J Diabetes Res. 2018 Jul 11;2018:1847430. (PMID: 30116734)
J Diabetes Investig. 2019 Jul;10(4):990-996. (PMID: 30582775)
J Diabetes Investig. 2019 May;10(3):685-689. (PMID: 30307126) - Contributed Indexing: Keywords: Autoantibody; False positive; Slowly-progressive type 1 diabetes
- Accession Number: 0 (Autoantibodies)
0 (Biomarkers)
EC 4.1.1.15 (Glutamate Decarboxylase) - Publication Date: Date Created: 20200530 Date Completed: 20210819 Latest Revision: 20210819
- Publication Date: 20231215
- Accession Number: PMC7610115
- Accession Number: 10.1111/jdi.13307
- Accession Number: 32469160
- Source:
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