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John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
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Otranto Road Library
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Mt. Pleasant Library
9 a.m. – 8 p.m.
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McClellanville Library
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John's Island Library
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Should calculation of chemotherapy dosage for bowel cancer be based on body composition?
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- Author(s): Kværner AS; Harnæs H; Alavi DH; Bärebring L; Henriksen HB; Guren MG; Lauritzen PM; Eggesbø HB; Wiedswang G; Smeland S; Blomhoff R
- Source:
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2020 May 19; Vol. 140 (8). Date of Electronic Publication: 2020 May 19 (Print Publication: 2020).- Publication Type:
Journal Article; Systematic Review- Language:
English; Norwegian - Source:
- Additional Information
- Transliterated Title: Bør beregning av cellegiftdose ved tarmkreft baseres på kroppssammensetning?
- Source: Publisher: Norske Laegeforening Country of Publication: Norway NLM ID: 0413423 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 0807-7096 (Electronic) Linking ISSN: 00292001 NLM ISO Abbreviation: Tidsskr Nor Laegeforen Subsets: MEDLINE
- Publication Information: Publication: Oslo : Norske Laegeforening
Original Publication: Chistiania : Alb. Cammermeyer, 1880- - Subject Terms:
- Abstract: Background: Dosage of chemotherapy for colon cancer is currently based on the patient's body surface area. Several studies have identified an association between low fat-free mass and chemotherapy toxicity among patients with metastatic colorectal cancer. This has been less widely studied for localised disease. This review aims to summarise studies that have investigated the association between clinical signs of disease-related malnutrition (low body mass index, weight loss and low muscle mass) and tolerance of chemotherapy in patients with localised colon cancer.
Material and Method: We conducted a systematic search in PubMed with various synonyms of the terms 'colorectal cancer', 'adjuvant chemotherapy', 'nutritional status' and 'toxicity'. The search was concluded in May 2019. Of 553 articles, 39 were considered relevant and read in full text. Ten of these fulfilled the inclusion criteria for this review.
Results: Nine of the ten studies indicate an association between clinical signs of disease-related malnutrition and dose-limiting toxicity. The association appears to be especially pronounced in patients with low fat-free mass.
Interpretation: The results support the hypothesis that there is an association between disease-related malnutrition and the prevalence of toxicity and modification of the course of adjuvant chemotherapy in patients with localised colon cancer. The potential benefits of basing chemotherapy dosage on body composition in addition to body surface area should be investigated in clinical trials. - Publication Date: Date Created: 20200529 Date Completed: 20210601 Latest Revision: 20220531
- Publication Date: 20240628
- Accession Number: 10.4045/tidsskr.19.0769
- Accession Number: 32463187
- Transliterated Title:
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