The Role of Ca ²⁺ -NFATc1 Signaling and Its Modulation on Osteoclastogenesis.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Calcium Signaling* ; Osteogenesis*; NFATC Transcription Factors/*metabolism ; Osteoclasts/*metabolism; Animals ; Humans ; NFATC Transcription Factors/genetics ; Osteoclasts/cytology ; Transient Receptor Potential Channels/genetics ; Transient Receptor Potential Channels/metabolism

The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeting the various activation processes in osteoclastogenesis provides various therapeutic strategies for bone loss. Diverse compounds that modulate calcium signaling have been applied to regulate osteoclast differentiation and, subsequently, attenuate bone loss. Thus, in this review, we summarized the modulation of the NFATc1 pathway through various compounds that regulate calcium signaling and the calcium influx machinery. Furthermore, we addressed the involvement of transient receptor potential channels in osteoclastogenesis.

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2019R1F1A1046785 (JHH), 2020R1A2C2003409 (DMS) Ministry of Science and ICT, South Korea

Keywords: NFAT; calcium signaling; osteoclast; transient receptor potential channels

0 (NFATC Transcription Factors)
0 (Transient Receptor Potential Channels)

Date Created: 20200528 Date Completed: 20210216 Latest Revision: 20210216

20221213

PMC7279283

10.3390/ijms21103646

32455661