Age Group Differences in Executive Network Functional Connectivity and Relationships with Social Behavior in Men with Autism Spectrum Disorder.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101300021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1750-9467 (Print) NLM ISO Abbreviation: Res Autism Spectr Disord Subsets: PubMed not MEDLINE

Original Publication: Amsterdam : Elsevier

Background: Research suggests adults with autism spectrum disorder (ASD) may use executive functions to compensate for social difficulties. Given hallmark age-related declines in executive functioning and the executive brain network in normal aging, there is concern that older adults with ASD may experience further declines in social functioning as they age. In a male-only sample, we hypothesized: 1) older adults with ASD would demonstrate greater ASD-related social behavior than young adults with ASD, 2) adults with ASD would demonstrate a greater age group reduction in connectivity of the executive brain network than neurotypical (NT) adults, and 3) that behavioral and neural mechanisms of executive functioning would predict ASD-related social difficulties in adults with ASD.
Methods: Participants were a cross-sectional sample of non-intellectually disabled young (ages 18-25) and middle-aged (ages 40-70) adult men with ASD and NT development (young adult ASD: n =24; middle-age ASD: n =25; young adult NT: n =15; middle-age NT: n =21). We assessed ASD-related social behavior via the self-report Social Responsiveness Scale-2 (SRS-2) Total Score, with exploratory analyses of the Social Cognition Subscale. We assessed neural executive function via connectivity of the resting-state executive network (EN) as measured by independent component analysis. Correlations were investigated between SRS-2 Total Scores (with exploratory analyses of the Social Cognition Subscale), EN functional connectivity of the dorsolateral prefrontal cortex (dlPFC), and a behavioral measure of executive function, Tower of London (ToL) Total Moves.
Results: We did not confirm a significant age group difference for adults with ASD on the SRS-2 Total Score; however, exploratory analysis revealed middle-age men with ASD had higher scores on the SRS-2 Social Cognition Subscale than young adult men with ASD. Exacerbated age group reductions in EN functional connectivity were confirmed (left dlPFC) in men with ASD compared to NT, such that older adults with ASD demonstrated the greatest levels of hypoconnectivity. A significant correlation was confirmed between dlPFC connectivity and the SRS-2 Total Score in middle-age men with ASD, but not young adult men with ASD. Furthermore, exploratory analysis revealed a significant correlation with the SRS-2 Social Cognition Subscale for young and middle-aged ASD groups and ToL Total Moves.
Conclusions: Our findings suggest that ASD-related difficulties in social cognition and EN hypoconnectivity may get worse with age in men with ASD and is related to executive functioning. Further, exacerbated EN hypoconnectivity associated with older age in ASD may be a mechanism of increased ASD-related social cognition difficulties in older adults with ASD. Given the cross-sectional nature of this sample, longitudinal replication is needed.
Competing Interests: Conflict of Interest The authors of this study have no financial, personal, or other relationships that may pose a potential conflicts of interest related to this research.

Autism Res. 2017 May;10(5):911-939. (PMID: 27874266)
Cereb Cortex. 2007 Apr;17(4):951-61. (PMID: 16772313)
J Neurosci. 2007 Feb 28;27(9):2349-56. (PMID: 17329432)
Trends Cogn Sci. 2010 Jun;14(6):277-90. (PMID: 20493761)
J Autism Dev Disord. 2012 Nov;42(11):2354-63. (PMID: 22361924)
AJNR Am J Neuroradiol. 2017 Feb;38(2):336-342. (PMID: 28056453)
Cogn Affect Behav Neurosci. 2012 Jun;12(2):241-68. (PMID: 22282036)
J Autism Dev Disord. 2007 Oct;37(9):1735-47. (PMID: 17146700)
J Autism Dev Disord. 2015 Jun;45(6):1579-87. (PMID: 25398602)
J Psychiatr Res. 1975 Nov;12(3):189-98. (PMID: 1202204)
J Autism Dev Disord. 2016 Sep;46(9):2859-73. (PMID: 27278313)
Neuroimage. 2012 Aug 15;62(2):1299-310. (PMID: 22245355)
Biol Psychiatry. 2011 May 1;69(9):832-8. (PMID: 21310395)
Curr Opin Psychiatry. 2017 Mar;30(2):69-76. (PMID: 28067726)
Clin Psychol Rev. 2014 Feb;34(1):73-86. (PMID: 24424351)
J Autism Dev Disord. 2018 Dec;48(12):4193-4206. (PMID: 29980900)
J Neurosci Methods. 2013 Feb 15;213(1):105-22. (PMID: 23261654)
J Autism Dev Disord. 2016 Aug;46(8):2666-2678. (PMID: 27177894)
Child Neuropsychol. 2016;22(3):336-44. (PMID: 25731979)
Trends Cogn Sci. 2012 Nov;16(11):533-40. (PMID: 23036719)
Schizophr Bull. 2009 Jan;35(1):67-81. (PMID: 19074498)
J Autism Dev Disord. 2012 May;42(5):665-75. (PMID: 21656030)
J Autism Dev Disord. 2011 Sep;41(9):1256-66. (PMID: 21153873)
Hum Brain Mapp. 2007 Nov;28(11):1251-66. (PMID: 17274023)
Neuroimage. 2002 May;16(1):61-75. (PMID: 11969318)
J Abnorm Psychol. 2015 Nov;124(4):1014-1026. (PMID: 26595478)
Autism. 2012 Nov;16(6):557-67. (PMID: 21846667)
Neurosci Biobehav Rev. 2012 Apr;36(4):1292-313. (PMID: 22353426)
Hum Brain Mapp. 1998;6(3):160-88. (PMID: 9673671)
J Autism Dev Disord. 2016 Feb;46(2):467-77. (PMID: 26349921)
Clin Neuropsychol. 2005 Sep-Dec;19(3-4):464-523. (PMID: 16120537)
J Child Psychol Psychiatry. 2015 Aug;56(8):893-902. (PMID: 25418509)
Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Sep;2(6):464-475. (PMID: 28924621)
Br J Psychiatry. 1990 Dec;157:853-9. (PMID: 2289094)
J Pers Assess. 1996 Dec;67(3):588-97. (PMID: 8991972)
J Am Geriatr Soc. 2011 Nov;59(11):2151-5. (PMID: 22091837)
Eur J Epidemiol. 2014 Feb;29(2):133-40. (PMID: 24553905)
Soc Neurosci. 2009;4(2):135-52. (PMID: 18633829)
Neuroimaging Clin N Am. 2017 Nov;27(4):561-579. (PMID: 28985929)
Autism Res. 2017 Dec;10(12):1945-1959. (PMID: 28940848)
J Autism Dev Disord. 2017 Oct;47(10):3204-3219. (PMID: 28730417)
J Am Acad Child Adolesc Psychiatry. 2013 Jun;52(6):572-81.e1. (PMID: 23702446)
Brain Behav. 2016 Mar 30;6(5):e00456. (PMID: 27069771)
J Child Psychol Psychiatry. 2019 Jan;60(1):102-110. (PMID: 29582425)
Philos Trans R Soc Lond B Biol Sci. 1982 Jun 25;298(1089):199-209. (PMID: 6125971)
PLoS One. 2014 Oct 01;9(10):e108807. (PMID: 25271846)
Neurosci Biobehav Rev. 2017 Sep;80:729-742. (PMID: 28642070)
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):1001-13. (PMID: 16087444)
Neuroimage. 2015 Jan 15;105:536-51. (PMID: 25462692)
Trends Cogn Sci. 2004 Jan;8(1):26-32. (PMID: 14697400)
Neuron. 2007 Oct 4;56(1):185-96. (PMID: 17920024)
Front Hum Neurosci. 2013 Nov 22;7:802. (PMID: 24319422)
J Autism Dev Disord. 1994 Oct;24(5):659-85. (PMID: 7814313)
Neuroimage. 2017 Oct 15;160:32-40. (PMID: 28159687)
Psychol Med. 2016 Mar;46(4):699-716. (PMID: 26707895)
Hum Brain Mapp. 2017 Jan;38(1):82-96. (PMID: 27511627)
Front Psychol. 2015 May 21;6:663. (PMID: 26052298)
Soc Cogn Affect Neurosci. 2013 Aug;8(6):694-701. (PMID: 22563003)
Neuroimage. 2010 Oct 15;53(1):247-56. (PMID: 20621638)
Neuroimage. 2014 Jul 15;95:287-304. (PMID: 24657353)
J Autism Dev Disord. 2001 Feb;31(1):5-17. (PMID: 11439754)
J Autism Dev Disord. 2016 Nov;46(11):3469-3480. (PMID: 27549589)
J Autism Dev Disord. 2016 Jun;46(6):1916-1930. (PMID: 26861713)
Hum Brain Mapp. 2017 Jan;38(1):396-413. (PMID: 27627877)
Q J Exp Psychol (Hove). 2012;65(11):2073-92. (PMID: 22906000)
J Autism Dev Disord. 2018 Jun;48(6):2038-2051. (PMID: 29349671)
Biol Psychiatry. 2016 Jul 15;80(2):120-128. (PMID: 26707088)

K01 MH116098 United States MH NIMH NIH HHS

Keywords: Aging; Autism Spectrum Disorder; Executive Functions; Executive Network; Social Behavior; fMRI

Date Created: 20200515 Latest Revision: 20220414

20231215

PMC7220036

10.1016/j.rasd.2019.02.008

32405319