A novel method for calculating mean erythrocyte age using erythrocyte creatine.

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  • Author(s): Kameyama M;Kameyama M; Koga M; Koga M; Okumiya T; Okumiya T
  • Source:
    Aging [Aging (Albany NY)] 2020 May 11; Vol. 12 (9), pp. 8702-8709. Date of Electronic Publication: 2020 May 11.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-4589 (Electronic) Linking ISSN: 19454589 NLM ISO Abbreviation: Aging (Albany NY) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Albany, NY : Impact Journals, LLC
    • Subject Terms:
      Erythrocyte Aging*; Anemia, Hemolytic/*blood ; Creatine/*blood ; Erythrocytes/*cytology; Anemia, Hemolytic/physiopathology ; Female ; Humans ; Male ; Regression Analysis
    • Abstract:
      Estimating the lifespan of erythrocytes is useful for the differential diagnosis of anemia. However, measuring the lifespan of erythrocytes was very difficult; therefore, it was seldom measured. Erythrocyte creatine (EC) decreases reflecting erythrocyte age. We developed a method to obtain mean erythrocyte age ( M RBC ) from EC .We reanalyzed the previously published data from 21 patients with hemolytic anemia, which included EC and the half-life of 51 Cr. M RBC and log e EC showed excellent significant linearity ( r = -0.9475, p < 0.001), proving that it could be treated as a mono-exponential relationship within the studied range ( EC : 1.45 - 11.76 μmol/g Hb). We established an equation to obtain M RBC (days) from EC (μmol/g Hb): M RBC = -22.84log e EC + 65.83.This equation allowed calculation of M RBC based on EC which has practical applications such as the diagnosis of anemia.
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    • Contributed Indexing:
      Keywords: average RBC age; creatine; erythrocyte; hemolysis; lifespan
    • Accession Number:
      MU72812GK0 (Creatine)
    • Publication Date:
      Date Created: 20200512 Date Completed: 20210226 Latest Revision: 20240328
    • Publication Date:
      20250114
    • Accession Number:
      PMC7244067
    • Accession Number:
      10.18632/aging.103193
    • Accession Number:
      32392179