Soluble Interleukin-2 Receptor Index Predicts Outcomes After Cord Blood Transplantation.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE
    • Publication Information:
      Publication: New York, N.Y. : Elsevier Science Inc.
      Original Publication: New York Stratton.
    • Subject Terms:
      Biomarkers/*blood ; Cord Blood Stem Cell Transplantation/*adverse effects ; Graft vs Host Disease/*blood ; Neoplasm Recurrence, Local/*blood ; Receptors, Interleukin-2/*metabolism; Adult ; Cord Blood Stem Cell Transplantation/mortality ; Female ; Graft vs Host Disease/epidemiology ; Graft vs Host Disease/etiology ; Hematologic Neoplasms/surgery ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasm Recurrence, Local/epidemiology ; Receptors, Interleukin-2/analysis ; Retrospective Studies
    • Abstract:
      Background: Our previous study demonstrated that the soluble interleukin-2 receptor (sIL-2R) index, defined as the ratio of serum sIL-2R levels at neutrophil engraftment to that before conditioning, is a biomarker that can predict acute graft-vs-host disease (GVHD) after unrelated bone marrow transplantation. In the present study, we evaluated the significance of the sIL-2R index among patients who underwent cord blood transplantation (CBT).
      Methods: We retrospectively analyzed 31 patients who underwent single-unit CBT as their first transplantation for hematologic malignancies.
      Results: The median sIL-2R index was 4.2. The cumulative incidence of grade II to IV acute GVHD was not associated with the sIL-2R index. However, the cumulative incidence of relapse at 3 years after transplantation was significantly lower, with an sIL-2R index ≥ 3.7 than with an index < 3.7 (12.8% vs 50.0%; P = .04). As a result, the probability of overall survival at 3 years after transplantation was significantly higher in the former group than in the latter (79.8% vs 20.0%; P < .01). Only the dose of corticosteroid administered in the pre-engraftment period influenced the sIL-2 index.
      Conclusion: The sIL-2R index can predict the incidence of relapse and probability of survival after CBT, possibly reflecting a graft-vs-leukemia effect.
      (Copyright © 2020 Elsevier Inc. All rights reserved.)
    • Accession Number:
      0 (Biomarkers)
      0 (Receptors, Interleukin-2)
    • Publication Date:
      Date Created: 20200512 Date Completed: 20210506 Latest Revision: 20210506
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.transproceed.2020.03.027
    • Accession Number:
      32389487