Plasma concentrations of vitamin K1 and PIVKA-II in bottle-fed and breast-fed infants with and without vitamin K prophylaxis at birth.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7603873 Publication Model: Print Cited Medium: Print ISSN: 0340-6199 (Print) Linking ISSN: 03406199 NLM ISO Abbreviation: Eur J Pediatr Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin, New York, Springer-Verlag.
    • Subject Terms:
      Biomarkers* ; Breast Feeding*; Bottle Feeding/*methods ; Protein Precursors/*blood ; Prothrombin/*blood ; Vitamin K 1/*blood; Half-Life ; Humans ; Infant ; Infant, Newborn ; Protein Precursors/metabolism ; Prothrombin/metabolism ; Umbilical Cord/analysis ; Vitamin K/administration & dosage
    • Abstract:
      Plasma vitamin K1 and proteins induced by vitamin K absence (PIVKA) were assayed simultaneously 1-4 days and 29-35 days after delivery in three groups of infants: breast-fed not receiving vitamin K at birth (n = 12), bottle-fed without vitamin K administration at birth (n = 7) and breast-fed receiving 1 mg vitamin K1 administered by intramuscular injection at birth (n = 13). The bottle-fed infants had a significantly higher vitamin K1 plasma level than breast-fed infants who did not receive vitamin K1 at birth. Extremely high levels of vitamin K were obtained 1-4 days after intramuscular administration. At the age of 1 month, breast-fed infants had the same plasma vitamin K1 concentration whether or not they had received vitamin K1 supplements. Decarboxy prothrombin (PIVKA-II) a reliable indicator of biochemical vitamin K deficiency, was found in 5 out of 12 breast-fed and in 2 out of 6 bottle-fed infants who had not received supplemental vitamin K1 after birth. In a separate study, we followed up to 90 days after birth a larger group if infants. PIVKA-II was found with significantly greater frequency in breast-fed infants receiving no vitamin K than in breast-fed infants receiving 1 mg vitamin K intramuscularly at birth, or in bottle-fed infants without extra vitamin K1. These data form a strong argument for routine vitamin K prophylaxis after birth for all breast-fed infants. The optimum dose and manner of administration require further study.
    • References:
      J Pediatr. 1985 Mar;106(3):351-9. (PMID: 3973772)
      Lancet. 1982 Aug 28;2(8296):460-3. (PMID: 6125638)
      Pediatr Res. 1985 Apr;19(4):354-7. (PMID: 4000762)
      Helv Paediatr Acta. 1986 May;41(1-2):25-9. (PMID: 3721893)
      J Lipid Res. 1982 Sep;23(7):1068-72. (PMID: 7142815)
      J Chromatogr Sci. 1986 Feb;24(2):76-9. (PMID: 3949938)
      J Nutr. 1982 Jun;112(6):1105-17. (PMID: 7086539)
      Lancet. 1983 Jun 25;1(8339):1439-40. (PMID: 6134196)
      J Chromatogr. 1984 Jan 13;305(1):61-72. (PMID: 6707155)
      Lancet. 1985 Aug 3;2(8449):242-4. (PMID: 2862419)
      J Pediatr. 1985 Oct;107(4):608-11. (PMID: 4045610)
      Lancet. 1984 Aug 4;2(8397):283. (PMID: 6146829)
      Arch Dis Child. 1985 Sep;60(9):814-8. (PMID: 4051538)
      Arch Dis Child. 1987 Apr;62(4):370-5. (PMID: 3592727)
    • Accession Number:
      0 (Biomarkers)
      0 (Protein Precursors)
      12001-79-5 (Vitamin K)
      53230-14-1 (acarboxyprothrombin)
      84-80-0 (Vitamin K 1)
      9001-26-7 (Prothrombin)
    • Publication Date:
      Date Created: 19881101 Date Completed: 19890501 Latest Revision: 20190813
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/BF00445922
    • Accession Number:
      3234435