Kisspeptin and Testicular Function-Is it Necessary?

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Kisspeptins/*genetics ; Kisspeptins/*metabolism ; Testis/*metabolism; Animals ; Gene Expression Regulation ; Humans ; Kisspeptins/pharmacology ; Male ; Signal Transduction ; Spermatogenesis/genetics ; Steroids/biosynthesis

The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/KISS1R) within the testes of species studied to date. There is substantial evidence of localised KISS1/KISS1R expression and peptide distribution in the testes. However, variability is observed in the testicular cell types expressing KISS1/KISS1R. Evidence is presented for modulation of steroidogenesis and sperm function by kisspeptin signaling. However, the physiological importance of such effects, and whether these are paracrine or endocrine manifestations, remain unclear.
Competing Interests: The authors declare no conflicts of interest.

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17/68/01 United Kingdom DH_ Department of Health; PDF-2017-10-098 United Kingdom DH_ Department of Health

Keywords: FSH; LH; Leydig cells; Sertoli cells; kisspeptin; kisspeptin receptor; spermatogenesis; spermatozoa; testes; testosterone

0 (Kisspeptins)
0 (Steroids)

Date Created: 20200426 Date Completed: 20210125 Latest Revision: 20210304

20240829

PMC7216047

10.3390/ijms21082958

32331420