[Autologous hematopoietic stem cell transplantation for systemic sclerosis : Position statement of the stem cell therapy working party of the German Society of Rheumatology].

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  • Additional Information
    • Transliterated Title:
      Autologe hämatopoetische Stammzelltransplantation bei systemischer Sklerose : Positionspapier des Arbeitskreises Stammzelltherapie der Deutschen Gesellschaft für Rheumatologie.
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 0414162 Publication Model: Print Cited Medium: Internet ISSN: 1435-1250 (Electronic) Linking ISSN: 03401855 NLM ISO Abbreviation: Z Rheumatol Subsets: MEDLINE
    • Publication Information:
      Publication: 2006- : Heidelberg : Springer
      Original Publication: Darmstadt, Steinkopff.
    • Subject Terms:
      Hematopoietic Stem Cell Transplantation* ; Rheumatology*/standards ; Scleroderma, Systemic*/therapy; Germany ; Humans ; Quality of Life ; Transplantation, Autologous
    • Abstract:
      There have been three randomized controlled trials on autologous hematopoietic stem cell transplantation (AHSCT) in systemic sclerosis (SSc) that demonstrated significant superiority with respect to survival, improvement of cutaneous fibrosis, lung function and quality of life compared to standard treatment; however, these advantages must be carefully weighed against the transplantation-related risks. For this reason, an expert group from the stem cell therapy working party of the German Society for Rheumatology (DGRh) has now developed recommendations for the use of AHSCT in SSc. Based on the high-quality evidence, AHSCT is considered as the standard option for the treatment of selected SSc patients. Potential candidates for AHSCT are those with early, rapidly progressive, diffuse cutaneous SSc with visceral manifestations who have not yet developed severe damage to internal organs. A close cooperation between rheumatologists and transplantation centers is crucial for optimizing patient selection and treatment outcomes.
    • Contributed Indexing:
      Keywords: Autologous stem cell transplantation; Cell therapy; DGRh; Guidelines; Systemic sclerosis
    • Publication Date:
      Date Created: 20200424 Date Completed: 20200916 Latest Revision: 20200916
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s00393-020-00789-0
    • Accession Number:
      32322977