Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE
    • Publication Information:
      Publication: San Diego, CA : Elsevier
      Original Publication: New York.
    • Subject Terms:
      Body Patterning* ; Wnt Signaling Pathway*; Bone Morphogenetic Proteins/*metabolism ; Embryo, Nonmammalian/*embryology ; Membrane Glycoproteins/*metabolism ; Xenopus Proteins/*metabolism; Animals ; Bone Morphogenetic Proteins/genetics ; Membrane Glycoproteins/genetics ; Protein Domains ; Xenopus Proteins/genetics ; Xenopus laevis
    • Abstract:
      Animal development and homeostasis depend on precise temporal and spatial intercellular signaling. Components shared between signaling pathways, generally thought to decrease specificity, paradoxically can also provide a solution to pathway coordination. Here we show that the Bone Morphogenetic Protein (BMP) and Wnt signaling pathways share Apcdd1 as a common inhibitor and that Apcdd1 is a taxon-restricted gene with novel domains and signaling functions. Previously, we showed that Apcdd1 inhibits Wnt signaling (Shimomura et al., 2010), here we find that Apcdd1 potently inhibits BMP signaling in body axis formation and neural differentiation in chicken, frog, zebrafish. Furthermore, we find that Apcdd1 has an evolutionarily novel protein domain. Our results from experiments and modeling suggest that Apcdd1 may coordinate the outputs of two signaling pathways that are central to animal development and human disease.
      (Copyright © 2020 Elsevier Inc. All rights reserved.)
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    • Grant Information:
      R01 HD091846 United States HD NICHD NIH HHS; R03 HD057334 United States HD NICHD NIH HHS; K12 HD052896 United States HD NICHD NIH HHS; P30 AR044535 United States AR NIAMS NIH HHS; R01 NS085097 United States NS NINDS NIH HHS; R01 HD073104 United States HD NICHD NIH HHS; R01 DC003806 United States DC NIDCD NIH HHS; R01 AR052579 United States AR NIAMS NIH HHS
    • Contributed Indexing:
      Keywords: Apcdd1; Bi-functional protein; Chicken; Embryonic development; Mouse; Wnt and BMP signaling Inhibitor; Xenopus; Zebrafish
    • Accession Number:
      0 (Apcdd1 protein, Xenopus)
      0 (Bone Morphogenetic Proteins)
      0 (Membrane Glycoproteins)
      0 (Xenopus Proteins)
    • Publication Date:
      Date Created: 20200423 Date Completed: 20210119 Latest Revision: 20240922
    • Publication Date:
      20240922
    • Accession Number:
      PMC7307705
    • Accession Number:
      10.1016/j.ydbio.2020.03.015
    • Accession Number:
      32320685