Pioneer factors and their in vitro identification methods.

Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101093320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1617-4623 (Electronic) Linking ISSN: 16174623 NLM ISO Abbreviation: Mol Genet Genomics Subsets: MEDLINE

Original Publication: Berlin : Springer-Verlag, c2001-

DNA/*genetics ; DNA-Binding Proteins/*genetics ; Molecular Biology/*methods ; Transcription Factors/*genetics; GATA4 Transcription Factor/genetics ; Gene Expression Regulation, Developmental/genetics ; Hepatocyte Nuclear Factor 3-alpha/genetics ; Humans ; Molecular Biology/trends ; Nucleosomes/genetics ; Protein Binding/genetics

Pioneer transcription factors are a special group of transcription factors that can interact with nucleosomal DNA and initiate regulatory events. Their binding to regulatory regions is the first event in gene activation and can occur in silent or heterochromatin regions. Several research groups have endeavored to define pioneer factors and study their binding characteristics using various techniques. In this review, we describe the in vitro methods used to define and characterize pioneer factors, paying particular attention to differences in methodologies and how these differences can affect results.

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R01 GM132199 United States GM NIGMS NIH HHS; 2017YFA0205203 National Key Research and Development Program of China; 81901857 National Natural Science Foundation of China; 81771957 National Natural Science Foundation of China

Keywords: Binding assays; Nucleosomes; Pioneer factors; Transcription factors

0 (DNA-Binding Proteins)
0 (FOXA1 protein, human)
0 (GATA4 Transcription Factor)
0 (GATA4 protein, human)
0 (Hepatocyte Nuclear Factor 3-alpha)
0 (Nucleosomes)
0 (Transcription Factors)
9007-49-2 (DNA)

Date Created: 20200417 Date Completed: 20200625 Latest Revision: 20210101

20240829

PMC7405852

10.1007/s00438-020-01675-9

32296927