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Increased expression of immune checkpoint programmed cell death protein-1 (PD-1) on T cell subsets of bone marrow aspirates in patients with B-Lymphoblastic leukemia, especially in relapse and at diagnosis.
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- Author(s): Park SH;Park SH; You E; You E; Park CJ; Park CJ; Cho YU; Cho YU; Jang S; Jang S; Im HJ; Im HJ; Seo JJ; Seo JJ; Park HS; Park HS; Lee JH; Lee JH
- Source:
Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2020 Jul; Vol. 98 (4), pp. 336-347. Date of Electronic Publication: 2020 Apr 08.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 101235690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4957 (Electronic) Linking ISSN: 15524949 NLM ISO Abbreviation: Cytometry B Clin Cytom Subsets: MEDLINE
- Publication Information: Original Publication: Hoboken, N.J. : Wiley-Liss, c2002-
- Subject Terms: B7-H1 Antigen/*genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics ; Programmed Cell Death 1 Ligand 2 Protein/*genetics ; Programmed Cell Death 1 Receptor/*genetics; Adult ; Apoptosis Regulatory Proteins/immunology ; B7-H1 Antigen/immunology ; CD8-Positive T-Lymphocytes/immunology ; Female ; Flow Cytometry ; Gene Expression Regulation, Leukemic/genetics ; Humans ; Immune Checkpoint Inhibitors/immunology ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Middle Aged ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Programmed Cell Death 1 Ligand 2 Protein/immunology ; Programmed Cell Death 1 Receptor/immunology ; Recurrence ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/pathology
- Abstract: Background: We analyzed expression profiles of immune checkpoint receptors on T cell subsets and ligands on leukemic blasts in patients with B-lymphoblastic leukemia (B-ALL).
Methods: Total 149 bone marrow (BM) samples obtained from 65 B-ALL patients with four different clinical status (41 at diagnosis, 54 in complete remission [CR], 34 in persistence, and 20 in relapse), and 32 BM control samples were prospectively enrolled. Expression of immune checkpoint receptor (programmed cell death protein-1 [PD-1]) on T cell subsets and ligands (PD-L1, PD-L2) on leukemic blasts was evaluated by flow cytometry, and was compared between patient subgroups.
Results: Relapsed patients demonstrated highest PD-1 expression proportion and intensity on CD3 + CD4 + T cells with statistical significance when compared to patients in persistence/CR/BM controls (p = .027/<.001/<.001 and .012/.001/<.001, respectively). Newly diagnosed patients showed significantly lower PD-1 expression proportion on CD3 + CD4 + T cells than relapsed patients (p < .001), but their intensity was not significantly different. Relapsed patients showed significantly higher PD-1 expression proportion and intensity on CD3 + CD8 + T cells than patients in CR/BM controls (p = .022/.045 and .049/.005, respectively), but PD-1 expression status on them were not significantly different between relapsed and newly diagnosed patients. PD-L1/L2 expression on leukemic blasts was not significantly different between patient subgroups.
Conclusions: In BM aspirates from B-ALL patients, PD-1 expression on T-cell subsets is increased at diagnosis, and to a greater extent, at relapse. These data suggest the potential usefulness of PD-1 blockade in the treatment of B-ALL, particularly at relapse.
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- Accession Number: 0 (Apoptosis Regulatory Proteins)
0 (B7-H1 Antigen)
0 (CD274 protein, human)
0 (Immune Checkpoint Inhibitors)
0 (PDCD1 protein, human)
0 (PDCD1LG2 protein, human)
0 (Programmed Cell Death 1 Ligand 2 Protein)
0 (Programmed Cell Death 1 Receptor) - Publication Date: Date Created: 20200409 Date Completed: 20210823 Latest Revision: 20210823
- Publication Date: 20221213
- Accession Number: 10.1002/cyto.b.21879
- Accession Number: 32268011
- Source:
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