Caffeine Consumption in Children: Innocuous or Deleterious? A Systematic Review.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE

Original Publication: Basel : MDPI, c2004-

Brain*/drug effects ; Caffeine*/adverse effects ; Caffeine*/pharmacology ; Central Nervous System Stimulants*/adverse effects ; Central Nervous System Stimulants*/pharmacology; Child ; Child Development ; Humans

Caffeine is the most consumed psychostimulant worldwide. Its use among children is controversial. Although it produces an increase in brain activity, it could hamper growth and development in young consumers. Therefore, the aim of this review was to recognize changes produced by caffeine in children under 12 years of age and to identify the relevant alterations and the conditions of their occurrence. A systematic review of the literature was carried out using PRISMA. Initially, 5468 articles were found from the EBSCO, ScienceDirect, PubMed, and Clarivate Analytics databases. In this review, were retained 24 published articles that met the inclusion criteria. The results obtained showed that caffeine consumption hampers children's growth and development. In contrast, it supports the activation of the central nervous system and brain energy management.

J Pediatr Psychol. 2008 May;33(4):358-67. (PMID: 17947257)
Br J Nutr. 2015 Feb 14;113(3):526-35. (PMID: 25612601)
Dev Period Med. 2016 Apr-Jun;20(2):150-6. (PMID: 27442701)
J Pediatr. 2011 Mar;158(3):508-9. (PMID: 21167501)
Pediatrics. 2014 Mar;133(3):386-93. (PMID: 24515508)
J Neonatal Perinatal Med. 2017;10(4):355-362. (PMID: 29286928)
J Food Sci. 2010 Apr;75(3):R77-87. (PMID: 20492310)
J Pediatr. 2014 Aug;165(2):356-359.e2. (PMID: 24840756)
Brain Cogn. 2009 Mar;69(2):316-27. (PMID: 18782649)
Crit Rev Food Sci Nutr. 2019;59(2):336-348. (PMID: 28853910)
J Psychopharmacol. 2017 May;31(5):561-568. (PMID: 28198658)
Middle East J Anaesthesiol. 2008 Feb;19(4):885-99. (PMID: 18630774)
Rev Panam Salud Publica. 2011 Oct;30(4):327-34. (PMID: 22124691)
Expert Rev Clin Pharmacol. 2018 Jun;11(6):545-547. (PMID: 29667442)
Int J Psychophysiol. 2009 Sep;73(3):355-61. (PMID: 19486913)
Biomed Res Int. 2015;2015:707149. (PMID: 26504823)
Phytother Res. 2019 Sep;33(9):2221-2243. (PMID: 31359516)
Subst Use Misuse. 2007;42(8):1237-51. (PMID: 17674233)
Sleep. 2011 Apr 01;34(4):503-7. (PMID: 21461329)
Pediatrics. 2011 Mar;127(3):511-28. (PMID: 21321035)
J Clin Sleep Med. 2017 Apr 15;13(4):533-543. (PMID: 28162144)
Med Sci Sports Exerc. 2008 May;40(5):871-8. (PMID: 18408611)
Biol Psychol. 2012 Mar;89(3):606-8. (PMID: 22266163)
J Paediatr Child Health. 2011 Apr;47(4):167-72. (PMID: 21244548)
Adv Nutr. 2015 Jan 15;6(1):102-11. (PMID: 25593149)
J Clin Sleep Med. 2014 Aug 15;10(8):897-901. (PMID: 25126037)
Pediatr Neonatol. 2017 Oct;58(5):391-397. (PMID: 28446386)
Med Clin (Barc). 2010 Oct 9;135(11):507-11. (PMID: 20206945)
J Hum Nutr Diet. 2014 Aug;27(4):342-57. (PMID: 25099503)
Crit Rev Food Sci Nutr. 2006;46(2):101-23. (PMID: 16507475)
J Pediatr Health Care. 2012 Jul-Aug;26(4):276-82. (PMID: 22726712)
BMC Pediatr. 2011 Aug 25;11:73. (PMID: 21867528)
J Sch Health. 2009 Aug;79(8):380-7. (PMID: 19630872)
Crit Rev Food Sci Nutr. 2018 May 24;58(8):1250-1259. (PMID: 28605236)
Ann Neurol. 2010 Nov;68(5):734-42. (PMID: 21031585)
Postgrad Med. 2015 Apr;127(3):308-22. (PMID: 25560302)
PLoS One. 2017 Nov 30;12(11):e0188668. (PMID: 29190753)
Pediatr Exerc Sci. 2015 Feb;27(1):50-6. (PMID: 25051124)
Pediatrics. 2018 May;141(5):. (PMID: 29643070)
J Clin Epidemiol. 2011 Dec;64(12):1325-30. (PMID: 21937195)
Nutrients. 2016 Mar 10;8(3):154. (PMID: 26978391)

Keywords: caffeine; children; development; growth; health effects; psychostimulant

0 (Central Nervous System Stimulants)
3G6A5W338E (Caffeine)

Date Created: 20200409 Date Completed: 20201019 Latest Revision: 20201019

20221213

PMC7177467

10.3390/ijerph17072489

32260589