Vitamin D Toxicity.

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  • Author(s): Lim K;Lim K; Thadhani R; Thadhani R; Thadhani R
  • Source:
    Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia [J Bras Nefrol] 2020 Apr 03; Vol. 42 (2), pp. 238-244.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English; Portuguese
  • Additional Information
    • Source:
      Publisher: Sociedade Brasileira de Nefrologia Country of Publication: Brazil NLM ID: 9426946 Publication Model: Print Cited Medium: Internet ISSN: 2175-8239 (Electronic) Linking ISSN: 01012800 NLM ISO Abbreviation: J Bras Nefrol Subsets: MEDLINE
    • Publication Information:
      Publication: São Paulo : Sociedade Brasileira de Nefrologia
      Original Publication: São Paulo, Brazil : Associação Medica Brasileira
    • Subject Terms:
      Acute Kidney Injury/*chemically induced ; Dietary Supplements/*toxicity ; Rickets/*prevention & control ; Vitamin D/*toxicity; Acute Kidney Injury/therapy ; Aged ; Dietary Supplements/supply & distribution ; Humans ; Hypercalcemia/chemically induced ; Hypercalcemia/complications ; Hypercalcemia/diagnosis ; Hypercalcemia/therapy ; Male ; Rickets/epidemiology ; Rickets/etiology ; Treatment Outcome ; Vitamin D/adverse effects ; Vitamin D/therapeutic use ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/drug therapy ; Withholding Treatment
    • Abstract:
      Fortification of food products with vitamin D was central to the eradication of rickets in the early parts of the 20th century in the United States. In the subsequent almost 100 years since, accumulating evidence has linked vitamin D deficiency to a variety of outcomes, and this has paralleled greater public interest and awareness of the health benefits of vitamin D. Supplements containing vitamin D are now widely available in both industrialized and developing countries, and many are in the form of unregulated formulations sold to the public with little guidance for safe administration. Together, this has contributed to a transition whereby a dramatic global increase in cases of vitamin D toxicity has been reported. Clinicians are now faced with the challenge of managing this condition that can present on a spectrum from asymptomatic to acute life-threatening complications. This article considers contemporary data on vitamin D toxicity, and diagnostic and management strategies relevant to clinical practice.
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    • Grant Information:
      K23 DK115683 United States DK NIDDK NIH HHS
    • Accession Number:
      1406-16-2 (Vitamin D)
    • Publication Date:
      Date Created: 20200408 Date Completed: 20210525 Latest Revision: 20210525
    • Publication Date:
      20221213
    • Accession Number:
      PMC7427646
    • Accession Number:
      10.1590/2175-8239-JBN-2019-0192
    • Accession Number:
      32255467