Beyond natural: synthetic expansions of botanical form and function.

Publisher: Wiley on behalf of New Phytologist Trust Country of Publication: England NLM ID: 9882884 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8137 (Electronic) Linking ISSN: 0028646X NLM ISO Abbreviation: New Phytol Subsets: MEDLINE

Publication: Oxford : Wiley on behalf of New Phytologist Trust
Original Publication: London, New York [etc.] Academic Press.

Biotechnology* ; Synthetic Biology*; Genetic Engineering ; Plants/genetics ; Systems Biology

Powered by developments that enabled genome-scale investigations, systems biology emerged as a field aiming to understand how phenotypes emerge from network functions. These advances fuelled a new engineering discipline focussed on synthetic reconstructions of complex biological systems with the goal of predictable rational design and control. Initially, progress in the nascent field of synthetic biology was slow due to the ad hoc nature of molecular biology methods such as cloning. The application of engineering principles such as standardisation, together with several key technical advances, enabled a revolution in the speed and accuracy of genetic manipulation. Combined with mathematical and statistical modelling, this has improved the predictability of engineering biological systems of which nonlinearity and stochasticity are intrinsic features leading to remarkable achievements in biotechnology as well as novel insights into biological function. In the past decade, there has been slow but steady progress in establishing foundations for synthetic biology in plant systems. Recently, this has enabled model-informed rational design to be successfully applied to the engineering of plant gene regulation and metabolism. Synthetic biology is now poised to transform the potential of plant biotechnology. However, reaching full potential will require conscious adjustments to the skillsets and mind sets of plant scientists.
(© 2020 The Author. New Phytologist © 2020 New Phytologist Trust.)

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BB/P010490/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/S020853/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BBS/E/T/000PR9815 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/L014130/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/R021554/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council

Keywords: bioengineering; metabolic engineering; plant biotechnology; plant synthetic biology; protein engineering

Date Created: 20200403 Date Completed: 20210514 Latest Revision: 20220913

20221213

PMC7383487

10.1111/nph.16562

32239523