[Preparation of Cangai oil transfersomes patches and its in vitro evaluation].

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  • Additional Information
    • Source:
      Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo
      Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989-
    • Subject Terms:
      Skin Absorption* ; Transdermal Patch*; Plant Oils/*pharmacology ; Skin/*drug effects; Administration, Cutaneous ; Drug Carriers ; Drug Liberation ; Humans ; Polymethacrylic Acids
    • Abstract:
      L_9(3~4) orthogonal experiment design was used to optimize the preparation of the patches,and investigate its affecting factors and skin irritation. Eugenol was taken as the index component to study the release behavior in vitro and percutaneous penetration of Cangai oil transfersomes patches by HPLC.The results showed that the optimal prescription for preparing Cangai oil transfersomes patches were Eudragit E100 0.6 g, succinic acid 0.08 g,triethyl citrate 0.25 g,glycerol 0.2 g.Patches prepared by the preferred preparation had a flat appearance without obvious bubbles.The initial adhesion was 18.33±2.52, the stickiness was(30.01±2.45) min,and the peel strength was(5.62±0.95) kN·m~(-1).The results of affecting factors experiment showed the order of factors affecting its adhesion was humidity>temperature>lighting,and the skin irritation test results showed no significant skin irritation after 24 h of single administration. The results of drug release behavior in vitro showed that the release and the percutaneous penetration of both Cangai oil patches and Cangai oil transfersomes patches conformed to the Higuchi equation.The release amount of eugenol were 80.66% and 82.25% at 72 h, with no significant difference. The cumulative permeation area of eugenol per unit area reached(0.195 6±0.065 9),(0.131 0±0.045 5) mg·cm~(-2) at 72 h, with significant differences(P<0.05).The experiment results proved that the preparation process of Cangai oil transfersomes patches was stable,and the prepared patches had a good adhesion. At the same time,the preparation of transfersomes patches could alleviate and control the release of the drug to a certain extent, and provide a certain experimental basis for clinical pediatric drug safety.
    • Contributed Indexing:
      Keywords: Cangai oil; eugenol; patches; quality evaluation; transfersomes
    • Accession Number:
      0 (Drug Carriers)
      0 (Plant Oils)
      0 (Polymethacrylic Acids)
      25086-15-1 (methylmethacrylate-methacrylic acid copolymer)
    • Publication Date:
      Date Created: 20200403 Date Completed: 20200721 Latest Revision: 20200721
    • Publication Date:
      20231215
    • Accession Number:
      10.19540/j.cnki.cjcmm.20191217.304
    • Accession Number:
      32237486