Alcohol-induced impaired insulin secretion in a Japanese population: 5-year follow up in the Gifu Diabetes Study.

Publisher: Asian Association for the Study of Diabetes and Blackwell Pub. Asia Country of Publication: Japan NLM ID: 101520702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1124 (Electronic) Linking ISSN: 20401116 NLM ISO Abbreviation: J Diabetes Investig Subsets: MEDLINE

Original Publication: Tokyo : Asian Association for the Study of Diabetes and Blackwell Pub. Asia

Insulin Secretion*; Alcohol Drinking/*adverse effects ; Diabetes Mellitus, Type 2/*epidemiology ; Glucose Intolerance/*epidemiology; Adult ; Aged ; Biomarkers/analysis ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/pathology ; Female ; Follow-Up Studies ; Glucose Intolerance/chemically induced ; Glucose Intolerance/pathology ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Factors

Aims/introduction: Although moderate alcohol consumption lowers the risk of type 2 diabetes in European populations, the same cannot be assumed for Japanese patients with diabetes related to low insulin secretion rather than resistance. We aimed to evaluate the effects of daily alcohol consumption on glucose tolerance and diabetes development risk in Japanese populations.
Materials and Methods: This retrospective study randomly enrolled 452 men and 659 women aged 40-78 years in 2005 (Gifu, Japan). The participants completed a 75-g oral glucose tolerance test and medical questionnaire. The homeostasis model assessment of insulin resistance, homeostasis model assessment of β-cell function and insulinogenic index were used to estimate insulin sensitivity and secretion. The relationships between alcohol consumption and these parameters were analyzed using logistic regression after adjusting for potential confounders. The 5-year changes in hemoglobin A1c levels were also evaluated.
Results: The adjusted odds ratios for elevated homeostasis model assessment of β-cell function values (<40%) in the 0-19.9 g/day, 20.0-39.9 g/day and ≥ 40 g/day alcohol consumption groups were 0.98, 1.46 and 2.68, respectively. Alcohol consumption induced a significant decrease in the insulin secretion level among the ≥40 g/day drinkers, especially in men. However, there was no risk of increased insulin resistance based on the homeostasis model assessment of insulin resistance (<2.5) results. The 5-year risk of elevated hemoglobin A1c levels (≥6.5%) was increased according to increase in alcohol consumption in both men and women.
Conclusions: Daily alcohol consumption was associated with reduced insulin secretion and an increased diabetes development risk in Japanese populations.
(© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)

J Diabetes Investig. 2020 Sep;11(5):1207-1214. (PMID: 32227447)
Diabetes Care. 2009 Nov;32(11):2123-32. (PMID: 19875607)
Diabetes Care. 2013 Jun;36(6):1789-96. (PMID: 23704681)
Diabetes Res Clin Pract. 2002 Sep;57(3):191-7. (PMID: 12126769)
Diabetes. 2000 Jun;49(6):975-80. (PMID: 10866050)
Diabetes Care. 2003 Jul;26(7):1971-8. (PMID: 12832298)
Circulation. 1993 Nov;88(5 Pt 1):2190-7. (PMID: 8222114)
J Diabetes. 2016 May;8(3):434-41. (PMID: 25991060)
Jpn J Clin Oncol. 1999 Jan;29(1):38-44. (PMID: 10073150)
Diabetes Care. 2003 Oct;26(10):2785-90. (PMID: 14514580)
Curr Diab Rep. 2015 Jun;15(6):602. (PMID: 25944304)
Diabetes Care. 2004 Jan;27(1):184-9. (PMID: 14693987)
Diabetes Care. 2000 Jan;23(1):18-22. (PMID: 10857962)
Diabetes. 2002 Jul;51(7):2170-8. (PMID: 12086947)
J Diabetes Investig. 2012 Feb 20;3(1):39-40. (PMID: 24843544)
Diabetol Int. 2015 Jul 22;7(2):148-154. (PMID: 30603258)
Diabetes Care. 1999 Sep;22(9):1432-7. (PMID: 10480505)
J Diabetes Investig. 2010 Oct 19;1(5):212-28. (PMID: 24843435)
Diabetes Metab. 2015 Apr;41(2):160-7. (PMID: 25451187)
Diabetes Care. 2005 Mar;28(3):719-25. (PMID: 15735217)
Diabet Med. 2012 Nov;29(11):1350-7. (PMID: 22957983)
Diabetes Care. 2004 Feb;27(2):354-61. (PMID: 14747213)
Am J Epidemiol. 1997 May 15;145(10):909-16. (PMID: 9149662)
Diabetes. 2001 Oct;50(10):2390-5. (PMID: 11574424)
J Med Syst. 1998 Feb;22(1):27-32. (PMID: 9554107)
J Epidemiol Community Health. 2002 Jul;56(7):542-8. (PMID: 12080164)
Diabetes Care. 2003 Jan;26(1):48-54. (PMID: 12502657)
Diabetologia. 2014 Jan;57(1):93-101. (PMID: 24105100)
Diabetes Care. 2003 Oct;26(10):2918-22. (PMID: 14514602)
Asia Pac J Clin Nutr. 2008;17(4):545-51. (PMID: 19114388)
BMJ. 1996 Oct 26;313(7064):1040-4. (PMID: 8898593)
Diabet Med. 1998 Jul;15(7):539-53. (PMID: 9686693)
Diabet Med. 2005 Mar;22(3):323-31. (PMID: 15717882)
Diabetes Care. 2005 Sep;28(9):2230-5. (PMID: 16123495)
Diabetes Care. 2010 Jan;33 Suppl 1:S11-61. (PMID: 20042772)
Metabolism. 2004 Jul;53(7):831-5. (PMID: 15254872)
J Obes. 2014;2014:634587. (PMID: 25140249)
J Epidemiol. 2003 Sep;13(5):251-8. (PMID: 14604220)
Diabetologia. 1985 Jul;28(7):412-9. (PMID: 3899825)

Investigator: K Adachi; M Araki; K Chimori; H Daidoh; K Fushimi; E Goshima; H Hayashi; M Hayashi; T Imai; M Ishii; M Izai; K Kamikubo; Y Kanoh; M Kitada; N Kojima; T Kojima; T Komaki; J Kosaka; H Maekawa; M Murayama; M Matsuda; I Matsui; Y Morimoto; Y Morioka; H Murase; K Nagai; T Nagashima; N Noda; N Noritake; K Ohmae; S Ozeki; S Sakata; H Sarui; M Sato; M Sugimoto; E Suzuki; N Takeda; R Totani; T Wada; Y Wada; M Yokoyama; K Yoshino
Keywords: Alcohol consumption; Insulin secretion; Japanese

0 (Biomarkers)

Date Created: 20200401 Date Completed: 20210914 Latest Revision: 20240329

20240329

PMC7477527

10.1111/jdi.13260

32227447