Burden of asthma exacerbations and health care utilization in pediatric patients with asthma in the US and England.

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  • Additional Information
    • Source:
      Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2050-4527 (Electronic) Linking ISSN: 20504527 NLM ISO Abbreviation: Immun Inflamm Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Oxford] : John Wiley and Sons Ltd, [2013]-
    • Subject Terms:
      Disease Progression*; Asthma/*drug therapy ; Asthma/*epidemiology ; Patient Acceptance of Health Care/*statistics & numerical data; Adolescent ; Anti-Asthmatic Agents/therapeutic use ; Child ; Cost of Illness ; Databases, Factual ; England/epidemiology ; Female ; Hospitalization/statistics & numerical data ; Humans ; Male ; Outcome Assessment, Health Care ; Retrospective Studies ; Severity of Illness Index ; United States/epidemiology
    • Abstract:
      Background: Data on asthma burden in pediatric patients are limited; this real-world study investigated exacerbation frequency and health care resource utilization (HCRU) in pediatric asthma patients from the US and England.
      Methods: Data from pediatric patients (aged 6-17 years) in the Optum claims database (US) or Clinical Practice Research Datalink with linkage to Hospital Episode Statistics (England) were analyzed. Patients were categorized into four hierarchical groups: treated asthma (patients with ≥1 baseline asthma medication), severe asthma (plus Global Initiative for Asthma Step 4/5), severe refractory asthma ([SRA] plus ≥2 baseline severe asthma exacerbations), and eosinophilic SRA (SRA plus blood eosinophil count ≥150 cells/µL). Exacerbation frequency and HCRU during the 12 months postindex were described.
      Results: Of 151 549 treated asthma patients in the US, 18 086 had severe asthma, 2099 SRA, and 109 eosinophilic SRA. There were 32 893 treated asthma patients in England, of whom 2711 had severe asthma, 265 SRA, and 8 eosinophilic SRA. In the 12 months postindex, ≥1 exacerbation occurred in 12.4% and 10.8% of patients with severe asthma, and 32.6% and 42.6% with SRA in the US and England, respectively. The proportions of patients with ≥1 asthma hospitalization in the 30 days after the first asthma exacerbation were 2.7% and 4.4% (treated), 3.5% and 8.2% (severe asthma), and 6.0% and 16.8% (SRA) in the US and England, respectively.
      Conclusion: This study provides insights into current asthma management practices in the US and England and indicates that some patients with severe disease have an unmet need for effective management.
      (© 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
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    • Contributed Indexing:
      Keywords: asthma; health care; pediatrics
    • Accession Number:
      0 (Anti-Asthmatic Agents)
    • Publication Date:
      Date Created: 20200330 Date Completed: 20210511 Latest Revision: 20210511
    • Publication Date:
      20231215
    • Accession Number:
      PMC7212194
    • Accession Number:
      10.1002/iid3.299
    • Accession Number:
      32222038