Oxysterols of helminth parasites and pathogenesis of foodborne hepatic trematodiasis caused by Opisthorchis and Fasciola species.

Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE

Original Publication: Berlin : Springer International, c1987-

Fasciola/*metabolism ; Foodborne Diseases/*parasitology ; Opisthorchis/*metabolism ; Oxysterols/*metabolism ; Trematode Infections/*parasitology; Animals ; Bile Duct Neoplasms/chemically induced ; Bile Duct Neoplasms/parasitology ; Carcinogenesis ; Cholangiocarcinoma/chemically induced ; Cholangiocarcinoma/parasitology ; Humans ; Oxysterols/toxicity

The foodborne trematodiases refer to a cluster of zoonotic neglected tropical diseases caused by trematodes, with transmission involving ingestion of contaminated plants, fishes, and crustaceans. Over 40 million people are infected with foodborne trematodes and 750 million are at risk of infection. From a public health point of view, important species include Clonorchis sinensis, Opisthorchis viverrini, Opisthorchis felineus, Fasciola hepatica, and Fasciola gigantica. Infection with C. sinensis and O. viverrini is classified as a group 1 biological carcinogen and a major risk factor for cholangiocarcinoma. The carcinogenic potential of the infection with O. felineus is less clear but recent biochemical and histopathological findings revealed that opisthorchiasis felinea also fits this pattern. By contrast, evidence of carcinogenic potential of infection with F. hepatica or F. gigantica, close phylogenetics relatives of Opisthorchis, is less certain. Oxysterols have been essentially described in animal model of opisthorchiasis and associated cholangiocarcinoma. Several oxysterol-like metabolites have been detected not only on developmental stages of O. viverrini and O. felineus but also on biofluids from experimentally infected hamsters as products of the activities of the liver flukes. These sterol derivatives are metabolized to active quinones that can modify host DNA. We have postulated that helminth parasite-associated sterols might induce tumor-like phenotypes in biliary epithelia, the cells of origin of liver fluke infection-associated cholangiocarcinoma, through the formation of DNA adducts, dysregulation of apoptosis, and other homeostatic pathways. Here we review, interpret, and discuss findings of oxysterol-like metabolites detected in liver flukes and their role in carcinogenesis, aiming to enhance understanding the pathogenesis of foodborne trematodiasis caused by Opisthorchis and Fasciola species. In future, further investigations will be necessary in order to comprehend relationship between liver flukes' oxysterols and their role in infection-associated diseases in humans.

N Engl J Med. 2007 Sep 6;357(10):1018-27. (PMID: 17804846)
World Health Organ Tech Rep Ser. 1995;849:1-157. (PMID: 7740791)
Exp Parasitol. 2011 Jul;128(3):291-7. (PMID: 21354145)
Mutagenesis. 1999 Mar;14(2):217-20. (PMID: 10229924)
Clin Microbiol Rev. 2009 Jul;22(3):466-83. (PMID: 19597009)
Br J Surg. 2002 Aug;89(8):962-70. (PMID: 12153620)
Acta Trop. 2003 Nov;88(3):221-7. (PMID: 14611876)
J Hepatol. 2013 Mar;58(3):575-82. (PMID: 23085249)
Mutat Res. 2001 Dec 12;484(1-2):69-76. (PMID: 11733073)
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Apr;101(3):475-9. (PMID: 1354124)
Adv Parasitol. 2007;65:239-96. (PMID: 18063098)
Lancet Infect Dis. 2012 Mar;12(3):210-21. (PMID: 22108757)
PLoS Negl Trop Dis. 2015 Dec 01;9(12):e0004258. (PMID: 26625139)
J Gastroenterol. 2014 Jan;49(1):64-72. (PMID: 23616173)
Free Radic Biol Med. 2005 Feb 15;38(4):535-44. (PMID: 15649656)
PLoS Med. 2007 Jul;4(7):e201. (PMID: 17622191)
BMC Genomics. 2019 May 22;20(1):399. (PMID: 31117933)
PLoS Negl Trop Dis. 2016 Sep 28;10(9):e0004962. (PMID: 27681524)
Int J Parasitol. 2005 Oct;35(11-12):1255-78. (PMID: 16150452)
Mol Carcinog. 1994 Oct;11(2):81-9. (PMID: 7916996)
Hum Pathol. 2016 Nov;57:61-67. (PMID: 27396933)
Carcinogenesis. 2017 Sep 1;38(9):929-937. (PMID: 28910999)
Arzneimittelforschung. 1984;34(9B):1167-9. (PMID: 6542384)
Genomics. 2001 Dec;78(3):185-96. (PMID: 11735225)
Biochem Biophys Res Commun. 2003 Sep 26;309(3):567-71. (PMID: 12963027)
Lipids Health Dis. 2011 Mar 09;10:44. (PMID: 21388551)
Am J Trop Med Hyg. 2013 Dec;89(6):1212-3. (PMID: 24080633)
Trends Parasitol. 2012 Oct;28(10):395-407. (PMID: 22947297)
Carcinogenesis. 1994 Feb;15(2):271-5. (PMID: 7508824)
Am J Physiol. 1994 Jun;266(6 Pt 1):G1060-70. (PMID: 8023938)
Acta Trop. 2011 Sep;120 Suppl 1:S158-68. (PMID: 20655862)
Mutat Res. 1994 Mar 1;305(2):241-52. (PMID: 7510035)
Lancet Infect Dis. 2005 Jan;5(1):31-41. (PMID: 15620559)
Arzneimittelforschung. 1984;34(9B):1164-7. (PMID: 6542383)
Clin Lipidol. 2012 Oct 1;7(5):537-548. (PMID: 23630545)
Turk J Gastroenterol. 2012;23(5):604-7. (PMID: 23161310)
Mol Aspects Med. 2014 Apr;36:1-55. (PMID: 23994691)
Int J Parasitol. 1997 Sep;27(9):1025-9. (PMID: 9363484)
Parasitol Int. 2012 Mar;61(1):10-6. (PMID: 21893213)
Exp Parasitol. 2016 Oct;169:81-9. (PMID: 27475124)
Hepatology. 2004 Mar;39(3):732-8. (PMID: 14999691)
Mod Pathol. 2007 Jun;20(6):701-9. (PMID: 17431410)
Adv Parasitol. 2010;72:305-50. (PMID: 20624536)
Korean J Parasitol. 2014 Apr;52(2):193-6. (PMID: 24850964)
Elife. 2019 Jan 15;8:. (PMID: 30644359)
Hepatology. 2009 Oct;50(4):1273-81. (PMID: 19676135)
Parasitol Int. 2012 Mar;61(1):25-31. (PMID: 21840415)
Front Genet. 2014 Dec 23;5:444. (PMID: 25566326)
Case Rep Gastroenterol. 2011 Sep;5(3):569-77. (PMID: 22110417)
Cancer Sci. 2010 Mar;101(3):579-85. (PMID: 20085587)
Cancer Discov. 2017 Oct;7(10):1116-1135. (PMID: 28667006)
Mol Aspects Med. 2009 Jun;30(3):111-22. (PMID: 19248801)
J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):169-80. (PMID: 21397019)
Trends Cancer. 2015 Nov 1;1(3):174-182. (PMID: 26618199)
Parasitol Int. 2013 Dec;62(6):535-42. (PMID: 23973383)
Trans R Soc Trop Med Hyg. 2016 Jan;110(1):28-36. (PMID: 26740360)
Arterioscler Thromb Vasc Biol. 1999 May;19(5):1190-200. (PMID: 10323769)
Tumour Biol. 2017 Mar;39(3):1010428317692247. (PMID: 28345469)
Parasitology. 2006;133 Suppl:S43-61. (PMID: 17274848)
Cancer. 1981 Mar 1;47(5 Suppl):1055-64. (PMID: 7016297)
Int J Parasitol. 2013 Nov;43(12-13):1031-46. (PMID: 23978669)
Toxicol Pathol. 2000 May-Jun;28(3):405-14. (PMID: 10862557)
Parasitol Int. 2017 Aug;66(4):458-463. (PMID: 26453019)
Acta Trop. 2018 Feb;178:196-204. (PMID: 29191519)
Nat Rev Gastroenterol Hepatol. 2011 Aug 02;8(9):512-22. (PMID: 21808282)
Clin Transl Med. 2016 Mar;5(1):12. (PMID: 26979321)
BJR Case Rep. 2016 May 8;2(3):20160038. (PMID: 30363979)
Int J Cancer. 2006 Jun 15;118(12):3030-44. (PMID: 16404738)
Parasitol Int. 2012 Mar;61(1):130-5. (PMID: 21704729)
PLoS Negl Trop Dis. 2015 Apr 02;9(4):e0003563. (PMID: 25836334)
Biochem Biophys Res Commun. 2005 Apr 1;329(1):386-90. (PMID: 15721318)
J Med Assoc Thai. 1983 Aug;66(8):464-9. (PMID: 6644209)
Am J Trop Med Hyg. 2019 Mar;100(3):599-603. (PMID: 30594265)
IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241. (PMID: 7715068)
Cancer Res. 1978 Dec;38(12):4634-9. (PMID: 214229)
Biochim Biophys Acta. 2006 Aug;1766(1):63-78. (PMID: 16675129)
Free Radic Biol Med. 2000 Jan 15;28(2):208-18. (PMID: 11281288)
Virchows Arch. 2013 Apr;462(4):421-7. (PMID: 23446751)
Med Sci Monit. 2011 Jun;17(6):CR329-33. (PMID: 21629187)
Mol Biochem Parasitol. 2012 Feb;181(2):190-4. (PMID: 22115821)
Biol Chem. 2006 Apr;387(4):365-72. (PMID: 16606333)
Hepatology. 2005 Jan;41(1):5-15. (PMID: 15690474)
Curr Opin Lipidol. 2001 Oct;12(5):529-33. (PMID: 11561172)
J Clin Invest. 2008 Apr;118(4):1311-21. (PMID: 18382743)
Nat Commun. 2014 Jul 09;5:4378. (PMID: 25007141)
PLoS One. 2017 Mar 31;12(3):e0173456. (PMID: 28362822)
Cancer Lett. 2015 Apr 10;359(2):226-32. (PMID: 25615421)
Arterioscler Thromb Vasc Biol. 2001 Jul;21(7):1124-30. (PMID: 11451740)

R01 CA155297 United States CA NCI NIH HHS; IF/00092/2014/CP1255/CT0004 Fundação para a Ciência e a Tecnologia

Keywords: Carcinogenesis; Fasciolasis; Opisthorchiasis; Oxysterols

0 (Oxysterols)

Date Created: 20200325 Date Completed: 20200706 Latest Revision: 20210917

20231215

10.1007/s00436-020-06640-4

32206886