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Association of omentin-1, adiponectin, and resistin genetic polymorphisms with systemic lupus erythematosus in a Chinese population.
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- Author(s): Zhang TP;Zhang TP; Li HM; Li HM; Li R; Li R; Zhang Q; Zhang Q; Fan YG; Fan YG; Li XM; Li XM; Pan HF; Pan HF; Ye DQ; Ye DQ
- Source:
International immunopharmacology [Int Immunopharmacol] 2020 Jun; Vol. 83, pp. 106343. Date of Electronic Publication: 2020 Mar 13.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE
- Publication Information: Original Publication: Amsterdam ; New York : Elsevier Science, c2001-
- Subject Terms: Genotype*; Adiponectin/*genetics ; Cytokines/*genetics ; Lectins/*genetics ; Lupus Erythematosus, Systemic/*genetics ; Resistin/*genetics; Adult ; China ; Female ; GPI-Linked Proteins/genetics ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide
- Abstract: Objective: An increasing number of studies have demonstrated the roles of adipokines in systemic lupus erythematosus (SLE). We aimed to investigate the association of genetic variations of omentin-1, adiponectin, and resistin with SLE susceptibility.
Methods: We selected 623 SLE patients and 665 normal controls in the present study. Genotyping of omentin-1 rs2274907, rs35779394, rs79209815, and rs13376023; adiponectin rs16861194 and rs266729; and resistin rs1862513, rs3745368, and rs3745367 was conducted by TaqMan SNP genotyping assays.
Results: Overall, we found no significant differences in the allele or genotype frequencies of the nine studied SNPs between the SLE patients and controls. However, an increased frequency of the resistin rs3745368 variant was observed in the SLE patients under the dominant model (P = 0.024). In omentin-1, the rs13376023 A allele was found to be related to oral ulcers in SLE patients (P = 0.013), and the rs35779394 C and rs13376023 A allele frequencies were significantly lower in SLE patients with BMI ≥ 24 kg/m 2 (P = 0.019, P = 0.033, respectively). For resistin, the frequencies of the rs3745368 AA genotype and A allele were lower in SLE patients with discoid rash (P = 0.036, P = 0.011), and the rs3745368 A allele frequency was higher in SLE patients with lupus nephritis (P = 0.018). The resistin rs3745367 AA genotype and A allele frequencies were related to the occurrence of renal disorder in SLE patients (P = 0.024, P = 0.009). The haplotype analysis showed that the CGA haplotype of resistin was associated with susceptibility to SLE (P = 0.005). No significant associations of plasma omentin-1, adiponectin or resistin levels with their respective genotypes were found in SLE patients.
Conclusions: In summary, omentin-1, adiponectin and resistin SNPs are not associated with the genetic background of SLE in Chinese patients. However, omentin-1 and resistin genetic variations might contribute to several clinical phenotypes of SLE.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.) - Contributed Indexing: Keywords: Adiponectin; Genetic polymorphisms; Omentin-1; Resistin; Systemic lupus erythematosus
- Accession Number: 0 (Adiponectin)
0 (Cytokines)
0 (GPI-Linked Proteins)
0 (ITLN1 protein, human)
0 (Lectins)
0 (Resistin) - Publication Date: Date Created: 20200318 Date Completed: 20210308 Latest Revision: 20210308
- Publication Date: 20221213
- Accession Number: 10.1016/j.intimp.2020.106343
- Accession Number: 32179245
- Source:
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