4D Flow MR Imaging to Improve Microwave Ablation Prediction Models: A Feasibility Study in an In Vivo Porcine Liver.

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  • Additional Information
    • Source:
      Publisher: Society of Cardiovascular and Interventional Radiology Country of Publication: United States NLM ID: 9203369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7732 (Electronic) Linking ISSN: 10510443 NLM ISO Abbreviation: J Vasc Interv Radiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Reston, Va. : Society of Cardiovascular and Interventional Radiology, c1990-
    • Subject Terms:
      Ablation Techniques* ; Liver Circulation* ; Magnetic Resonance Imaging, Cine* ; Microwaves*; Hepatic Veins/*diagnostic imaging ; Liver/*blood supply ; Liver/*surgery ; Perfusion Imaging/*methods; Animals ; Blood Flow Velocity ; Feasibility Studies ; Hepatic Veins/physiopathology ; Models, Animal ; Predictive Value of Tests ; Sus scrofa
    • Abstract:
      Purpose: To characterize the effect of hepatic vessel flow using 4-dimensional (4D) flow magnetic resonance (MR) imaging and correlate their effect on microwave ablation volumes in an in vivo non-cirrhotic porcine liver model.
      Materials and Methods: Microwave ablation antennas were placed under ultrasound guidance in each liver lobe of swine (n = 3 in each animal) for a total of 9 ablations. Pre- and post-ablation 4D flow MR imaging was acquired to quantify flow changes in the hepatic vasculature. Flow measurements, along with encompassed vessel size and vessel-antenna spacing, were then correlated with final ablation volume from segmented MR images.
      Results: The linear regression model demonstrated that the preablation measurement of encompassed hepatic vein size (β = -0.80 ± 0.25, 95% confidence interval [CI] -1.15 to -0.22; P = .02) was significantly correlated to final ablation zone volume. The addition of hepatic vein flow rate found via 4D flow MRI (β = -0.83 ± 0.65, 95% CI -2.50 to 0.84; P = .26), and distance from antenna to hepatic vein (β = 0.26 ± 0.26, 95% CI -0.40 to 0.92; P = .36) improved the model accuracy but not significantly so (multivariate adjusted R 2  = 0.70 vs univariate (vessel size) adjusted R 2  = 0.63, P = .24).
      Conclusions: Hepatic vein size in an encompassed ablation zone was found to be significantly correlated with final ablation zone volume. Although the univariate 4D flow MR imaging-acquired measurements alone were not found to be statistically significant, its addition to hepatic vein size improved the accuracy of the ablation volume regression model. Pre-ablation 4D flow MR imaging of the liver may assist in prospectively optimizing thermal ablation treatment.
      (Copyright © 2019 SIR. Published by Elsevier Inc. All rights reserved.)
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    • Grant Information:
      UL1 TR001881 United States TR NCATS NIH HHS
    • Publication Date:
      Date Created: 20200318 Date Completed: 20201124 Latest Revision: 20211002
    • Publication Date:
      20221213
    • Accession Number:
      PMC7486998
    • Accession Number:
      10.1016/j.jvir.2019.11.034
    • Accession Number:
      32178944