Stain Protocol for the Detection of N-Terminal Amino Groups during Solid-Phase Peptide Synthesis.

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  • Author(s): Suzuki R;Suzuki R; Konno H; Konno H
  • Source:
    Organic letters [Org Lett] 2020 May 01; Vol. 22 (9), pp. 3309-3312. Date of Electronic Publication: 2020 Mar 05.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Chemical Society, c1999-
    • Subject Terms:
      Coloring Agents* ; Solid-Phase Synthesis Techniques*/methods; Amino Acids/chemistry ; Peptides/chemistry
    • Abstract:
      A novel and reversible detection method for N-terminal amino groups and alternative to the Kaiser test during Fmoc-SPPS has been developed. The utility of the new method was exemplified in its monitoring of the construction of a peptide, the final yield of which was higher than that of an identical peptide constructed under identical conditions but using the Kaiser test, and its scope was established to include all 20 proteinogenic amino acids as well as nonproteinogenic ones.
    • Accession Number:
      0 (Amino Acids)
      0 (Coloring Agents)
      0 (Peptides)
    • Publication Date:
      Date Created: 20200306 Date Completed: 20220530 Latest Revision: 20220530
    • Publication Date:
      20240829
    • Accession Number:
      10.1021/acs.orglett.0c00445
    • Accession Number:
      32134276