The relationship between calcium oxalate lithiasis and chronic proinflammatory intestinal dysbiosis pattern: a prospective study.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 101602699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2194-7236 (Electronic) Linking ISSN: 21947228 NLM ISO Abbreviation: Urolithiasis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin : Springer, [2013]-
    • Subject Terms:
      Calcium Oxalate/*analysis ; Dysbiosis/*complications ; Intestines/*microbiology ; Lithiasis/*chemistry ; Lithiasis/*complications; Female ; Humans ; Inflammation/complications ; Male ; Middle Aged ; Prospective Studies
    • Abstract:
      The objective is to establish whether a pattern of intestinal dysbiosis exists in calcium oxalate (CaOx) lithiasis and, if so, to identify its characteristics and explore whether there are differences in the pattern between CaOx dihydrate (COD) and monohydrate (COM) lithiasis. With this aim 24 patients diagnosed with CaOx lithiasis by means of optical microscopy and spectrometry were prospectively recruited. Faecal analysis was carried out by means of RT-PCR 16S rRNA assay and agar plate culture according to the methodology proposed by the Institute of Microecology (Herborn, Germany). The total number of bacteria was depleted due to COD lithiasis (p = 0.036). The mean values of immunoregulating microbiota were normal, but the percentage of normal values was lower in the COD group (30%) than in the COM group (69.2%) (p = 0.062). The total mean values of protective microbiota were normal in both groups. There was a large decrease in the mean values of the muconutritive microbiota Akkermansia muciniphila and Faecalibacterium prausnitzii, the most intense decline being observed in the COD group (p = 0.019). Levels of proteolytic microbiota were elevated in both groups, without differences between them. We conclude that patients with CaOx lithiasis have a chronic pro-inflammatory intestinal dysbiosis pattern characterised by a reduction in the total number of bacteria, a reduction in immunoregulating microbiota and a large reduction in muconutritive microbiota that is significantly more intense in COD lithiasis than in COM lithiasis.
    • Comments:
      Comment in: Urolithiasis. 2021 Apr;49(2):181-182. (PMID: 33200272)
    • Contributed Indexing:
      Keywords: Calcium oxalate dihydrate lithiasis; Calcium oxalate lithiasis; Calcium oxalate monohydrate lithiasis; Intestinal dysbiosis; Microbiota
    • Accession Number:
      2612HC57YE (Calcium Oxalate)
    • Publication Date:
      Date Created: 20200229 Date Completed: 20210412 Latest Revision: 20210920
    • Publication Date:
      20240829
    • Accession Number:
      10.1007/s00240-020-01181-y
    • Accession Number:
      32107580