N-terminal Pro B-type Natriuretic Peptide and High-sensitivity Cardiac Troponin as Markers for Heart Failure and Cardiovascular Disease Risks According to Glucose Status (from the Multi-Ethnic Study of Atherosclerosis [MESA]).

Publisher: Excerpta Medica Country of Publication: United States NLM ID: 0207277 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1913 (Electronic) Linking ISSN: 00029149 NLM ISO Abbreviation: Am J Cardiol Subsets: MEDLINE

Original Publication: New York, NY : Excerpta Medica

Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*metabolism ; Heart Failure/*metabolism ; Myocardial Ischemia/*metabolism ; Natriuretic Peptide, Brain/*metabolism ; Peptide Fragments/*metabolism ; Prediabetic State/*metabolism ; Stroke/*metabolism ; Troponin T/*metabolism; Aged ; Aged, 80 and over ; Angina Pectoris/epidemiology ; Angina Pectoris/metabolism ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Coronary Disease/metabolism ; Coronary Disease/mortality ; Female ; Heart Failure/epidemiology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/epidemiology ; Myocardial Infarction/metabolism ; Myocardial Ischemia/epidemiology ; Myocardial Ischemia/mortality ; Risk Assessment ; Stroke/epidemiology ; Stroke/mortality ; United States/epidemiology

The role of NT-proBNP and hs-cTnT levels in predicting heart failure (HF) and cardiovascular disease (CVD) events in persons with prediabetes (pre-DM) and diabetes mellitus (DM) is not well-established. We examined the individual and combined relations of N-terminal natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) levels among asymptomatic adults with pre-DM and DM with the development of incident HF and CVD events. 5,584 participants with biomarker measures aged 45 to 84 years were included from the Multi-Ethnic Study of Atherosclerosis, of which 4,090 were normoglycemic, 799 had pre-DM, and 695 had DM at baseline and were followed for 12.4 ± 3.8 years. In those with DM, HF incidence rates per 1,000 person-years ranged from 3.2 to 39.4 across quartiles of NT-proBNP and 0.6 to 18.2 for hs-cTnT, respectively. Corresponding values for CVD incidence per 1,000 person-years ranged from 13.7 to 39.4 for NT-proBNP and 13.2 to 35.4 for hs-cTnT. Multivariate adjusted HRs were highest when both NT-proBNP and hs-cTnT were above versus below the median in those with pre-DM/DM (16.7 for incident HF and 2.1 for CVD events, both p <0.01). In conclusion, the combination of both biomarkers to traditional risk factors in participants who were normoglycemic or with pre-DM or DM improved risk prediction for both incident HF and total CVD events in an ethnically diverse population.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

UL1 TR001420 United States TR NCATS NIH HHS; UL1 TR001079 United States TR NCATS NIH HHS; UL1 TR000040 United States TR NCATS NIH HHS; R01 HL127659 United States HL NHLBI NIH HHS

0 (Blood Glucose)
0 (Peptide Fragments)
0 (TNNT2 protein, human)
0 (Troponin T)
0 (pro-brain natriuretic peptide (1-76))
114471-18-0 (Natriuretic Peptide, Brain)

Date Created: 20200229 Date Completed: 20200803 Latest Revision: 20200803

20240628

10.1016/j.amjcard.2020.01.025

32106929