[Clinical observation of nasal spray allergen blocker combined with antihistamines in treatment of allergic rhinitis children].

Publisher: Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu Country of Publication: China NLM ID: 101303164 Publication Model: Print Cited Medium: Print ISSN: 2096-7993 (Print) Linking ISSN: 20967993 NLM ISO Abbreviation: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Subsets: MEDLINE

Original Publication: Wuhan Shi : Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu

Allergens* ; Nasal Sprays*; Histamine Antagonists/*therapeutic use ; Phthalazines/*therapeutic use ; Rhinitis, Allergic/*therapy; Administration, Intranasal ; Child ; Double-Blind Method ; Humans

Objective: To investigate the clinical effect and safety of nasal spray allergen blocker combined with antihistamines in children with allergic rhinitis. Method: Eighty-four children with mild-severe allergic rhinitis were randomly divided into observation group（42 cases） and control group（42 cases）. Children in control group were treated with azelastine hydrochloride nasal spray, while children in observation group added with nasal spray allergen blocker on the basis of control group. Both groups were treated for 4 weeks. The changes of symptoms and signs integral in both groups were compared and analyzed after 1, 2 and 4 weeks treatment. And Clinical efficacy and adverse reactions between two groups were compared after treatment. Result: Among 4 weeks treatment, the symptoms and signs integral of the two groups showed a significant decreasing trend（ P <0.01）. The reduction in the observation group was greater than that in the control group, there were statistical differences in the variation trends of symptoms and signs integral between the two groups（ P <0.01, P <0.05）. And there were significant differences in symptoms and signs integral between the two groups（ P <0.05）. The total effective rate of observation group（90.5%） was significantly higher than that of control group（64.3%）（ P <0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（9.5%vs 4.8%, P >0.05）. Conclusion: The effect of nasal spray allergen blocker combined with antihistamines on allergic rhinitis children is remarkable. They can alleviate the symptoms and signs of allergic rhinitis with rapidity and safety.
Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
(Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

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Keywords: allergen blocker; azelastine hydrochloride; child; rhinitis, allergic
Local Abstract: [Publisher, Chinese] 目的： 探讨鼻雾型过敏原阻隔剂联合抗组胺药对儿童变应性鼻炎（AR）的临床疗效及安全性。 方法： 将84例中重度AR患儿随机分为观察组和对照组，每组42例，对照组应用盐酸氮卓斯汀鼻喷剂治疗，观察组在对照组基础上联合应用鼻雾型过敏原阻隔剂治疗。于治疗1、2、4周后比较2组患儿鼻部症状及体征评分、临床疗效和不良反应发生情况。 结果： 2组治疗后鼻部症状评分及体征评分均呈逐渐下降趋势（均 P <0.01），观察组降低幅度大于对照组，2组的变化趋势差异有统计学意义（ P <0.01、 P <0.05），鼻部症状评分和体征评分2组间比较差异有统计学意义（均 P <0.05）。治疗后观察组总有效率为90.5%，显著高于对照组的64.3%（ P <0.05），2组不良反应发生率比较差异无统计学意义（9.5%、4.8%， P >0.05）。 结论： 鼻雾型过敏原阻隔剂联合抗组胺药治疗儿童AR疗效显著，可安全、快速地缓解患儿的临床症状及体征。.

0 (Allergens)
0 (Histamine Antagonists)
0 (Nasal Sprays)
0 (Phthalazines)

Date Created: 20200223 Date Completed: 20200310 Latest Revision: 20240917

20240917

PMC10128570

10.13201/j.issn.1001-1781.2020.01.015

32086901