NH 2 -MIL-53(Al) Polymer Monolithic Column for In-Tube Solid-Phase Microextraction Combined with UHPLC-MS/MS for Detection of Trace Sulfonamides in Food Samples.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      Food Analysis* ; Solid Phase Microextraction* ; Tandem Mass Spectrometry*; Polymers/*chemistry ; Sulfonamides/*analysis; Adsorption ; Animals ; Calibration ; Chickens ; Chromatography, High Pressure Liquid ; Fishes ; Hydrogen-Ion Concentration ; Metal-Organic Frameworks ; Rheology ; Spectroscopy, Fourier Transform Infrared ; Temperature ; X-Ray Diffraction
    • Abstract:
      In this study, a novel monolithic capillary column based on a NH 2 -MIL-53(Al) metal-organic framework (MOF) incorporated in poly (3-acrylamidophenylboronic acid/methacrylic acid-co-ethylene glycol dimethacrylate) (poly (AAPBA/MAA-co-EGDMA)) was prepared using an in situ polymerization method. The characteristics of the MOF-polymer monolithic column were investigated by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, Brunauer-Emmett-Teller analysis, and thermogravimetric analysis. The prepared MOF-polymer monolithic column showed good permeability, high extraction efficiency, chemical stability, and good reproducibility. The MOF-polymer monolithic column was used for in-tube solid-phase microextraction (SPME) to efficiently adsorb trace sulfonamides from food samples. A novel method combining MOF-polymer-monolithic-column-based SPME with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was successfully developed. The linear range was from 0.015 to 25.0 µg/L, with low limits of detection of 1.3-4.7 ng/L and relative standard deviations (RSDs) of < 6.1%. Eight trace sulfonamides in fish and chicken samples were determined, with recoveries of the eight analytes ranging from 85.7% to 113% and acceptable RSDs of < 7.3%. These results demonstrate that the novel MOF-polymer-monolithic-column-based SPME coupled with UHPLC-MS/MS is a highly sensitive, practical, and convenient method for monitoring trace sulfonamides in food samples previously extracted with an adequate solvent.
      Competing Interests: The authors declare no conflict of interest.
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    • Grant Information:
      KY2018078 Technological Talents in Universities of Guizhou Province; 21505115 National Natural Science Foundation of China; 2017014 Higher Education Improvement Project of Guizhou Province; LH20177026 Science and Technology Foundation of the Guizhou Provincial Science and Technology Department
    • Contributed Indexing:
      Keywords: metal-organic framework; monolithic capillary column; solid-phase microextraction; sulfonamides; ultra-high performance liquid chromatography-tandem mass spectrometry
    • Accession Number:
      0 (Metal-Organic Frameworks)
      0 (Polymers)
      0 (Sulfonamides)
    • Publication Date:
      Date Created: 20200223 Date Completed: 20201130 Latest Revision: 20231113
    • Publication Date:
      20231113
    • Accession Number:
      PMC7070345
    • Accession Number:
      10.3390/molecules25040897
    • Accession Number:
      32085411