Synthesis, characterization, and the antioxidant activity of the acetylated chitosan derivatives containing sulfonium salts.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Guildford, Eng., IPC Science and Technology Press.
    • Subject Terms:
      Antioxidants/*chemistry ; Chitosan/*chemistry ; Salts/*chemistry ; Sulfonium Compounds/*chemistry; Acetylation ; Biphenyl Compounds/chemistry ; Free Radical Scavengers/chemistry ; Hydroxyl Radical/chemistry ; Magnetic Resonance Spectroscopy/methods ; Picrates/chemistry ; Superoxides/chemistry
    • Abstract:
      In this study, a new class of chitosan derivatives possessing sulfonium salts was synthesized, and characterized by FT-IR, 1 H NMR, 13 C NMR, and elemental analyses. IR spectra, 1 H NMR and 13 C NMR of the structural units of these polymers validated the designed chitosan derivatives were successfully synthesized. In addition, the antioxidant potential of chitosan and chitosan derivatives was assessed in vitro, screened by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, hydroxyl radical scavenging, and superoxide radical scavenging, respectively. Results revealed that designed chitosan derivatives could effectively scavenge DPPH radical, hydroxyl radical, and superoxide radical with inhibition rate of more than 90% at 1.6 mg/mL, higher than chitosan. Moreover, in the cytotoxicity assay, no cytotoxicity was observed for the L929 cells with chitosan and its derivatives at all the testing concentrations. These results indicated that the acetylated chitosan derivatives containing sulfonium salts may be a promising natural antioxidant for the pharmaceutics, food, cosmetics and agriculture management.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2020 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antioxidant activity; Chitosan; Sulfonium salts
    • Accession Number:
      0 (Antioxidants)
      0 (Biphenyl Compounds)
      0 (Free Radical Scavengers)
      0 (Picrates)
      0 (Salts)
      0 (Sulfonium Compounds)
      11062-77-4 (Superoxides)
      3352-57-6 (Hydroxyl Radical)
      9012-76-4 (Chitosan)
      DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
    • Publication Date:
      Date Created: 20200222 Date Completed: 20210203 Latest Revision: 20210203
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.ijbiomac.2020.02.177
    • Accession Number:
      32084479