Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; New York : Elsevier, c2002-
    • Subject Terms:
      Antibodies, Bacterial*/analysis ; Antibodies, Bacterial*/blood ; Cystic Fibrosis*/epidemiology ; Cystic Fibrosis*/immunology ; Cystic Fibrosis*/microbiology ; Cystic Fibrosis*/surgery ; Pseudomonas Infections*/blood ; Pseudomonas Infections*/physiopathology; Antibody Formation/*immunology ; Lung Transplantation/*methods ; Pseudomonas aeruginosa/*immunology; Adult ; Chronic Disease ; Denmark/epidemiology ; Female ; Humans ; Immunoelectrophoresis/methods ; Immunologic Memory/immunology ; Male ; Postoperative Period ; Retrospective Studies
    • Abstract:
      Background: Specific Pseudomonas aeruginosa (PA) precipitating immunoglobulin G antibodies in serum are correlated with PA biofilm infection and are used as diagnostic and prognostic markers in cystic fibrosis (CF). The aim of this study was to examine the change of PA antibody response in CF patients after bilateral sequential lung transplantation (LTx).
      Methods: PA antibodies and airway bacteriology were retrospectively evaluated in 20 chronically infected CF patients, who underwent LTx between 2001 and 2016 at Rigshospitalet, Copenhagen. Yearly precipitin counts from one year before LTx and up to five years after LTx were compared. Monthly airway cultures were examined in the five-year period after LTx. In addition, crossed immunoelectrophoresis (CIE) were analysed for each patient for antigenic similarities from time of infection, pre-LTx and post-LTx.
      Results: All patients experienced a significant drop in PA antibodies from one year pre-LTx to one year post-LTx (p < 0.0001). The PA antibody level did not differ between those, who became reinfected immediately after LTx, and those, who did not. No patients regained the high pre-LTx precipitin levels in the following five years. The antigenic specificities of the sera post-LTx were in each patient similar to the antigenic specificities at the beginning of infection indicating a decades long memory of their immune response like an "immunological fingerprint".
      Conclusions: After LTx a significant and continuous reduction in PA antibodies was observed. The reduction was independent of immediate reinfection after LTx. A novel three-factor explanatory model is presented.
      Competing Interests: Declaration of Competing Interest CM is funded by the Novo Nordic Foundation Borregaard Clinical Scientist Fellowship Grant # NNF17OC00250074. The rest of the authors did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.
      (Copyright © 2020. Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: Cystic fibrosis; Humoral response; Lung transplantation; Pseudomonas aeruginosa
    • Accession Number:
      0 (Antibodies, Bacterial)
    • Publication Date:
      Date Created: 20200212 Date Completed: 20210913 Latest Revision: 20210913
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.jcf.2020.01.012
    • Accession Number:
      32044245