A comparative view on vitamin C effects on αβ- versus γδ T-cell activation and differentiation.

Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE

Publication: 2023- : Oxford : Oxford University Press
Original Publication: New York : Alan R. Liss, c1984-

Antioxidants/*pharmacology ; Ascorbic Acid/*pharmacology ; Epigenesis, Genetic/*drug effects ; Receptors, Antigen, T-Cell, alpha-beta/*genetics ; Receptors, Antigen, T-Cell, gamma-delta/*genetics ; T-Lymphocytes/*drug effects; Animals ; Cell Differentiation/drug effects ; Cell Lineage/drug effects ; Cell Lineage/genetics ; Cell Lineage/immunology ; Epigenesis, Genetic/immunology ; Humans ; Immunotherapy/methods ; Lymphocyte Activation/drug effects ; Mice ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Signal Transduction ; T-Lymphocytes/classification ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Thymus Gland/cytology ; Thymus Gland/immunology

Vitamin C (VitC) is an essential vitamin that needs to be provided through exogenous sources. It is a potent anti-oxidant, and an essential cofactor for many enzymes including a group of enzymes that modulate epigenetic regulation of gene expression. Moreover, VitC has a significant influence on T-cell differentiation, and can directly interfere with T-cell signaling. Conventional CD4 and CD8 T cells express the αβ TCR and recognize peptide antigens in the context of MHC presentation. The numerically small population of γδ T cells recognizes antigens in an MHC-independent manner. γδ T cells kill a broad variety of malignant cells, and because of their unique features, are interesting candidates for cancer immunotherapy. In this review, we summarize what is known about the influence of VitC on T-cell activation and differentiation with a special focus on γδ T cells. The known mechanisms of action of VitC on αβ T cells are discussed and extrapolated to the effects observed on γδ T-cell activation and differentiation. Overall, VitC enhances proliferation and effector functions of γδ T cells and thus may help to increase the efficacy of γδ T cells applied as cancer immunotherapy in adoptive cell transfer.
(©2020 Society for Leukocyte Biology.)

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Keywords: T-cell signaling; Vdelta2 T cells; gammadelta T cells; vitamin C

0 (Antioxidants)
0 (Receptors, Antigen, T-Cell, alpha-beta)
0 (Receptors, Antigen, T-Cell, gamma-delta)
PQ6CK8PD0R (Ascorbic Acid)

Date Created: 20200209 Date Completed: 20201104 Latest Revision: 20201104

20231215

10.1002/JLB.1MR1219-245R

32034803