Rare Breast Carcinoma with Paradoxical Plasma Cell Immunoprofile: A Case Report.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE
    • Publication Information:
      Publication: 2018- : Basel, Switzerland : MDPI
      Original Publication: Kaunas : Lietuvos gydytojų sąjunga
    • Subject Terms:
      Breast Neoplasms/*pathology ; Carcinoma, Lobular/*pathology ; Multiple Myeloma/*pathology ; Plasma Cells/*pathology ; Rare Diseases/*pathology; Adipose Tissue/pathology ; Aged ; Antibodies, Neoplasm ; Breast Neoplasms/immunology ; Carcinoma, Lobular/immunology ; Female ; Humans ; Immunoglobulin kappa-Chains/analysis ; Immunohistochemistry ; Multiple Myeloma/immunology ; Paraffin Embedding/methods ; Phenotype ; Plasma Cells/immunology ; Rare Diseases/immunology ; Syndecan-1/analysis
    • Abstract:
      Plasma cell features are encountered in a variety of non-plasma cell neoplasias, especially carcinomas of a discohesive type, such as those occurring in the digestive tract and breast. Lobular carcinomas of the breast present themselves in a variety of architectural patterns and many cell morphologies, including plasmacytoid types. A matching plasma cell phenotype is sometimes an associated feature. We report a case of a moderate grade invasive lobular carcinoma with focal plasmacytoid morphology and aberrant expression of plasma cell markers in a patient previously diagnosed with multiple myeloma. Paradoxical plasma cell immunoprofiles can be encountered in many malignancies, causing serious diagnostic problems, even more so with those occurring in discohesive carcinomas in multiple myeloma patients.
      Competing Interests: The authors declare no conflict of interest.
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    • Contributed Indexing:
      Keywords: lobular carcinoma; multiple myeloma; plasma cell differentiation
    • Accession Number:
      0 (Antibodies, Neoplasm)
      0 (Immunoglobulin kappa-Chains)
      0 (SDC1 protein, human)
      0 (Syndecan-1)
    • Publication Date:
      Date Created: 20200209 Date Completed: 20201109 Latest Revision: 20240727
    • Publication Date:
      20240727
    • Accession Number:
      PMC7074448
    • Accession Number:
      10.3390/medicina56020062
    • Accession Number:
      32033289