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Phthalates and Sex Steroid Hormones Among Men From NHANES, 2013-2016.
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- Author(s): Woodward MJ;Woodward MJ; Obsekov V; Obsekov V; Jacobson MH; Jacobson MH; Kahn LG; Kahn LG; Trasande L; Trasande L; Trasande L; Trasande L; Trasande L; Trasande L
- Source:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Apr 01; Vol. 105 (4).- Publication Type:
Journal Article; Research Support, N.I.H., Extramural- Language:
English - Source:
- Additional Information
- Source: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE
- Publication Information: Publication: 2017- : New York : Oxford University Press
Original Publication: Springfield, Ill. : Charles C. Thomas - Subject Terms:
- Abstract: Context: Phthalates are commonly found in commercial packaging, solvents, vinyl, and personal care products, and there is concern for potential endocrine-disrupting effects in males. The commonly used di-2-ethylhexyl phthalate (DEHP) has progressively been replaced by seldom studied compounds, such as bis-2-ethylhexyl terephthalate and 1,2-cyclohexane dicarboxylic acid di-isononyl ester (DINCH).
Objective: To investigate the associations between the urinary phthalate metabolites and serum sex steroid hormone concentrations in a nationally representative sample of adult males.
Design, Setting, Participants, and Intervention: This was a cross-sectional analysis of data from the 2013-2016 National Health and Nutrition Examination Survey among 1420 male participants aged ≥20 years.
Main Outcome Measures: Serum levels of total testosterone, estradiol, SHBG, and derived sex hormone measurements of free testosterone, bioavailable testosterone, and free androgen index were examined as log-transformed continuous variables.
Results: Phthalate metabolites were not statistically significantly associated with sex hormone concentrations among all men. However, associations varied by age. High molecular weight phthalates were associated with lower total, free, and bioavailable testosterone among men age ≥60. Specifically, each doubling of ΣDEHP was associated with 7.72% lower total testosterone among older men (95% confidence interval, -12.76% to -2.39%). Low molecular phthalates were associated with lower total, free, and bioavailable testosterone among men age 20 to 39 and ∑DINCH was associated with lower total testosterone among men age ≥40.
Conclusions: Our results indicate that males may be vulnerable to different phthalate metabolites in age-specific ways. These results support further investigation into the endocrine-disrupting effects of phthalates.
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Hum Reprod. 2015 Nov;30(11):2658-70. (PMID: 26385792) - Grant Information: K99 ES030403 United States ES NIEHS NIH HHS; P30 ES000260 United States ES NIEHS NIH HHS; R01 ES022972 United States ES NIEHS NIH HHS; R01 ES029779 United States ES NIEHS NIH HHS
- Accession Number: 0 (Biomarkers)
0 (Gonadal Steroid Hormones)
0 (Phthalic Acids)
6O7F7IX66E (phthalic acid) - Publication Date: Date Created: 20200131 Date Completed: 20210104 Latest Revision: 20240328
- Publication Date: 20240329
- Accession Number: PMC7067547
- Accession Number: 10.1210/clinem/dgaa039
- Accession Number: 31996892
- Source:
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