Visible-light Promoted Atom Transfer Radical Addition-Elimination (ATRE) Reaction for the Synthesis of Fluoroalkylated Alkenes Using DMA as Electron-Donor.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      Alkenes/*chemistry ; Hydrocarbons, Fluorinated/*chemical synthesis ; Iodides/*chemistry; Catalysis ; Hydrocarbons, Fluorinated/chemistry ; Photochemical Processes
    • Abstract:
      Here, we describe a mild, catalyst-free and operationally-simple strategy for the direct fluoroalkylation of olefins driven by the photochemical activity of an electron donor-acceptor (EDA) complex between DMA and fluoroalkyl iodides. The significant advantages of this photochemical transformation are high efficiency, excellent functional group tolerance, and synthetic simplicity, thus providing a facile route for further application in pharmaceuticals and life sciences.
      Competing Interests: The authors declare no conflict of interest.
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    • Grant Information:
      2017-1225, 2018-1427 Programs of Guizhou Province; 81760624, 21702241 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: DMA.; EDA; fluoroalkyl iodides; fluoroalkylated alkenes; noncovalent interaction
    • Accession Number:
      0 (Alkenes)
      0 (Hydrocarbons, Fluorinated)
      0 (Iodides)
    • Publication Date:
      Date Created: 20200130 Date Completed: 20201106 Latest Revision: 20201106
    • Publication Date:
      20240829
    • Accession Number:
      PMC7036948
    • Accession Number:
      10.3390/molecules25030508
    • Accession Number:
      31991642